Abstract
Introduction: Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides. Methods: To test whether B-cell-stimulating cytokines are increased in IgM-PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM-PNP and 113 controls. Results: Median interleukin (IL)-6 concentrations were higher in patients with IgM-PNP, and median IL-10 concentrations were higher in the subgroup with anti-MAG IgM antibodies. These serum concentrations were not increased in 110 patients with multifocal motor neuropathy. Discussion: Median IL-6 and IL-10 serum concentrations differ between patients with anti-MAG neuropathy and other patients with IgM-PNP compared with healthy and neuropathy controls. These differences may indicate differences in immune-mediated disease mechanisms. Muscle Nerve 59:694–698, 2019.
| Original language | English |
|---|---|
| Pages (from-to) | 694-698 |
| Number of pages | 5 |
| Journal | Muscle & Nerve |
| Volume | 59 |
| Issue number | 6 |
| Early online date | 7 Mar 2019 |
| DOIs | |
| Publication status | Published - Jun 2019 |
Keywords
- anti-MAG neuropathy
- cytokines
- monoclonal gammopathy
- multifocal motor neuropathy
- peripheral neuropathy
- Immunoglobulin M/immunology
- Humans
- Middle Aged
- Cytokines/immunology
- Male
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology
- Interleukin-2/immunology
- Interferon-gamma/immunology
- Interleukin-6/immunology
- Polyneuropathies/immunology
- Aged, 80 and over
- Interleukin-10/immunology
- Adult
- Female
- Paraproteinemias/immunology
- Myelin-Associated Glycoprotein/immunology
- Interleukin-12/immunology
- Autoantibodies/immunology
- Interleukin-4/immunology
- Interleukin-8/immunology
- Tumor Necrosis Factor-alpha/immunology
- B-Lymphocytes/immunology
- Granulocyte-Macrophage Colony-Stimulating Factor/immunology
- Aged