Serum apolipoprotein e level is not increased in Alzheimer's disease: The Rotterdam study

Arjen J.C. Slooter; Peter De Knijff; Albert Hofman; Marc Cruts; Monique M.B. Breteler; Christine Van Broeckhoven; Louis M. Havekes; Cornelia M. Van Duijn

doi:10.1016/S0304-3940(98)00339-5

Serum apolipoprotein e level is not increased in Alzheimer's disease: The Rotterdam study

Arjen J.C. Slooter^*
, Peter De Knijff
, Albert Hofman
, Marc Cruts
, Monique M.B. Breteler
, Christine Van Broeckhoven
, Louis M. Havekes
, Cornelia M. Van Duijn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

Abstract

The APOE*4 allele of the apolipoprotein E gene (APOE) is an important risk factor for Alzheimer's disease. It has been suggested that levels of apolipoprotein E (apoE) in plasma are increased in Alzheimer's disease. In this population-based study, we found that serum apoE levels were lower in Alzheimer patients compared to non-demented controls (0.75 μmol/l (SD 0.35), vs. 0.83 μmol/l (SD 0.40), P < 0.05). This finding is in accordance with lower serum apoE levels as observed in carriers of the APOE*4 allele, who are over-represented in Alzheimer's disease. After adjustment for age, sex, total protein, albumin level, body mass index and the APOE genotype, the difference in serum apoE levels largely disappeared. Our population-based study suggests that the differences in serum apoE level between Alzheimer patients and controls are mainly the result of differences in the distribution of the APOE genotype.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	Neuroscience Letters
Volume	248
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(98)00339-5
Publication status	Published - 22 May 1998
Externally published	Yes

Keywords

Alzheimer's disease
Apolipoprotein E
Atherosclerosis
Dementia
Plasma
Serum level

Access to Document

10.1016/S0304-3940(98)00339-5

Cite this

@article{ca57f88c931f4680b209394afecb0d21,

title = "Serum apolipoprotein e level is not increased in Alzheimer's disease: The Rotterdam study",

abstract = "The APOE*4 allele of the apolipoprotein E gene (APOE) is an important risk factor for Alzheimer's disease. It has been suggested that levels of apolipoprotein E (apoE) in plasma are increased in Alzheimer's disease. In this population-based study, we found that serum apoE levels were lower in Alzheimer patients compared to non-demented controls (0.75 μmol/l (SD 0.35), vs. 0.83 μmol/l (SD 0.40), P < 0.05). This finding is in accordance with lower serum apoE levels as observed in carriers of the APOE*4 allele, who are over-represented in Alzheimer's disease. After adjustment for age, sex, total protein, albumin level, body mass index and the APOE genotype, the difference in serum apoE levels largely disappeared. Our population-based study suggests that the differences in serum apoE level between Alzheimer patients and controls are mainly the result of differences in the distribution of the APOE genotype.",

keywords = "Alzheimer's disease, Apolipoprotein E, Atherosclerosis, Dementia, Plasma, Serum level",

author = "Slooter, \{Arjen J.C.\} and \{De Knijff\}, Peter and Albert Hofman and Marc Cruts and Breteler, \{Monique M.B.\} and \{Van Broeckhoven\}, Christine and Havekes, \{Louis M.\} and \{Van Duijn\}, \{Cornelia M.\}",

year = "1998",

month = may,

day = "22",

doi = "10.1016/S0304-3940(98)00339-5",

language = "English",

volume = "248",

pages = "21--24",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Serum apolipoprotein e level is not increased in Alzheimer's disease

T2 - The Rotterdam study

AU - Slooter, Arjen J.C.

AU - De Knijff, Peter

AU - Hofman, Albert

AU - Cruts, Marc

AU - Breteler, Monique M.B.

AU - Van Broeckhoven, Christine

AU - Havekes, Louis M.

AU - Van Duijn, Cornelia M.

PY - 1998/5/22

Y1 - 1998/5/22

N2 - The APOE*4 allele of the apolipoprotein E gene (APOE) is an important risk factor for Alzheimer's disease. It has been suggested that levels of apolipoprotein E (apoE) in plasma are increased in Alzheimer's disease. In this population-based study, we found that serum apoE levels were lower in Alzheimer patients compared to non-demented controls (0.75 μmol/l (SD 0.35), vs. 0.83 μmol/l (SD 0.40), P < 0.05). This finding is in accordance with lower serum apoE levels as observed in carriers of the APOE*4 allele, who are over-represented in Alzheimer's disease. After adjustment for age, sex, total protein, albumin level, body mass index and the APOE genotype, the difference in serum apoE levels largely disappeared. Our population-based study suggests that the differences in serum apoE level between Alzheimer patients and controls are mainly the result of differences in the distribution of the APOE genotype.

AB - The APOE*4 allele of the apolipoprotein E gene (APOE) is an important risk factor for Alzheimer's disease. It has been suggested that levels of apolipoprotein E (apoE) in plasma are increased in Alzheimer's disease. In this population-based study, we found that serum apoE levels were lower in Alzheimer patients compared to non-demented controls (0.75 μmol/l (SD 0.35), vs. 0.83 μmol/l (SD 0.40), P < 0.05). This finding is in accordance with lower serum apoE levels as observed in carriers of the APOE*4 allele, who are over-represented in Alzheimer's disease. After adjustment for age, sex, total protein, albumin level, body mass index and the APOE genotype, the difference in serum apoE levels largely disappeared. Our population-based study suggests that the differences in serum apoE level between Alzheimer patients and controls are mainly the result of differences in the distribution of the APOE genotype.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Atherosclerosis

KW - Dementia

KW - Plasma

KW - Serum level

UR - https://www.scopus.com/pages/publications/0032557509

U2 - 10.1016/S0304-3940(98)00339-5

DO - 10.1016/S0304-3940(98)00339-5

M3 - Article

C2 - 9665654

AN - SCOPUS:0032557509

SN - 0304-3940

VL - 248

SP - 21

EP - 24

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Serum apolipoprotein e level is not increased in Alzheimer's disease: The Rotterdam study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this