Seroconversion to HCoV-NL63 in Rhesus Macaques

Ronald Dijkman; H Lie Mulder; Lynne Rumping; Ilse Kraaijvanger; Martin Deijs; Maarten F Jebbink; Ernst J Verschoor; Lia van der Hoek

doi:10.3390/v1030647

Seroconversion to HCoV-NL63 in Rhesus Macaques

Ronald Dijkman, H Lie Mulder, Lynne Rumping, Ilse Kraaijvanger, Martin Deijs, Maarten F Jebbink, Ernst J Verschoor, Lia van der Hoek

Metabolic diseases research

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.

Original language	English
Pages (from-to)	647-56
Number of pages	10
Journal	Viruses [E]
Volume	1
Issue number	3
DOIs	https://doi.org/10.3390/v1030647
Publication status	Published - Dec 2009

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abstract = "HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.",

author = "Ronald Dijkman and Mulder, {H Lie} and Lynne Rumping and Ilse Kraaijvanger and Martin Deijs and Jebbink, {Maarten F} and Verschoor, {Ernst J} and {van der Hoek}, Lia",

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AU - Dijkman, Ronald

AU - Mulder, H Lie

AU - Rumping, Lynne

AU - Kraaijvanger, Ilse

AU - Deijs, Martin

AU - Jebbink, Maarten F

AU - Verschoor, Ernst J

AU - van der Hoek, Lia

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AB - HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.

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DO - 10.3390/v1030647

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JO - Viruses [E]

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Seroconversion to HCoV-NL63 in Rhesus Macaques

Abstract

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