TY - JOUR
T1 - Serial Assessment of Neurodevelopmental Outcome following Neonatal Encephalopathy and Therapeutic Hypothermia
AU - Parmentier, Corline E J
AU - van Steenis, Andrea
AU - Havekes, A J Fleur
AU - Steggerda, Sylke J
AU - Annink, Kim V
AU - Alderliesten, Thomas
AU - Lequin, Maarten H
AU - van Schooneveld, Monique M J
AU - van Klink, Jeanine M M
AU - Koopman-Esseboom, Corine
AU - Rijken, Monique
AU - Tan, Ratna N G B
AU - Benders, Manon J N L
AU - Groenendaal, Floris
AU - de Vries, Linda S
AU - van der Aa, Niek E
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/10
Y1 - 2025/10
N2 - Objective: To compare the neurodevelopmental outcome at 18-24 months, 5-6 years, and 8-10 years of age among children who received therapeutic hypothermia (TH) for neonatal encephalopathy (NE) following perinatal asphyxia. Study design: A retrospective, multicenter cohort study was performed in children with NE treated with TH at 2 level III neonatal intensive care units between January 2008 and December 2015, with neurodevelopmental testing at 18-24 months (visit 1), 5-6 years (visit 2), and 8-10 years (visit 3). Motor, cognitive, and behavioral scores, derived from standardized neurodevelopmental tests, were converted to Z-scores and compared across the visits using linear mixed modeling. Results: Seventy-seven children were analyzed. In linear mixed modeling, motor Z-scores decreased nonlinearly throughout the follow-up visits, being lower among children with a lower total IQ at 8-10 years and deep gray matter injury on neonatal brain magnetic resonance imaging. Cognitive Z-scores decreased among children with mammillary body abnormalities on neonatal magnetic resonance imaging, and were significantly lower in children with a lower gestational age and lower socioeconomic status. Z-scores indicating internalizing behavioral problems increased linearly (visit 1: median −0.7, IQR 1.4; visit 2: median −0.5, IQR 1.2; visit 3: median −0.1, IQR 1.5). Conclusions: Motor, cognitive, and behavioral Z-scores significantly worsened from 2 to 8-10 years among children who received TH for NE, highlighting the importance of long-term developmental surveillance.
AB - Objective: To compare the neurodevelopmental outcome at 18-24 months, 5-6 years, and 8-10 years of age among children who received therapeutic hypothermia (TH) for neonatal encephalopathy (NE) following perinatal asphyxia. Study design: A retrospective, multicenter cohort study was performed in children with NE treated with TH at 2 level III neonatal intensive care units between January 2008 and December 2015, with neurodevelopmental testing at 18-24 months (visit 1), 5-6 years (visit 2), and 8-10 years (visit 3). Motor, cognitive, and behavioral scores, derived from standardized neurodevelopmental tests, were converted to Z-scores and compared across the visits using linear mixed modeling. Results: Seventy-seven children were analyzed. In linear mixed modeling, motor Z-scores decreased nonlinearly throughout the follow-up visits, being lower among children with a lower total IQ at 8-10 years and deep gray matter injury on neonatal brain magnetic resonance imaging. Cognitive Z-scores decreased among children with mammillary body abnormalities on neonatal magnetic resonance imaging, and were significantly lower in children with a lower gestational age and lower socioeconomic status. Z-scores indicating internalizing behavioral problems increased linearly (visit 1: median −0.7, IQR 1.4; visit 2: median −0.5, IQR 1.2; visit 3: median −0.1, IQR 1.5). Conclusions: Motor, cognitive, and behavioral Z-scores significantly worsened from 2 to 8-10 years among children who received TH for NE, highlighting the importance of long-term developmental surveillance.
KW - magnetic resonance imaging
KW - neonatal encephalopathy
KW - neurodevelopmental outcome
KW - perinatal asphyxia
UR - https://www.scopus.com/pages/publications/105008912271
U2 - 10.1016/j.jpeds.2025.114679
DO - 10.1016/j.jpeds.2025.114679
M3 - Article
C2 - 40482878
SN - 0022-3476
VL - 285
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
M1 - 114679
ER -