Sensory and sensorimotor gating in children with multiple complex developmental disorders (MCDD) and autism.

Bob Oranje; B. Lahuis; H. Van Engeland; R. Van der Gaag; C. Kemner

doi:10.1016/j.psychres.2012.10.014

Sensory and sensorimotor gating in children with multiple complex developmental disorders (MCDD) and autism.

Bob Oranje^*, B. Lahuis, H. Van Engeland, R. Van der Gaag, C. Kemner

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Multiple Complex Developmental Disorder (MCDD) is a well-defined and validated behavioral subtype of autism with a proposed elevated risk of developing a schizophrenic spectrum disorder. The current study investigated whether children with MCDD show the same deficits in sensory gating that are commonly reported in schizophrenia, or whether they are indistinguishable from children with autism in this respect. P50 suppression and prepulse inhibition (PPI) of the startle reflex were assessed in children with MCDD (n=14) or autism (n=13), and healthy controls (n=12), matched on age and IQ. All subjects showed high levels of PPI and P50 suppression. However, no group differences were found. No abnormalities in sensory filtering could be detected in children with autism or MCDD. Since sensory gating deficits are commonly regarded as possible endophenotypic markers for schizophrenia, the current results do not support a high level of similarity between schizophrenia and MCDD. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	287-292
Number of pages	6
Journal	Psychiatry Research
Volume	206
Issue number	2-3
DOIs	https://doi.org/10.1016/j.psychres.2012.10.014
Publication status	Published - 30 Apr 2013

Keywords

P50 suppression
PPI
Startle reflex

Access to Document

10.1016/j.psychres.2012.10.014

http://www.ncbi.nlm.nih.gov/pubmed/23164481

Cite this

@article{da1de445b7924066a440eac5f6b06bf1,

title = "Sensory and sensorimotor gating in children with multiple complex developmental disorders (MCDD) and autism.",

abstract = "Multiple Complex Developmental Disorder (MCDD) is a well-defined and validated behavioral subtype of autism with a proposed elevated risk of developing a schizophrenic spectrum disorder. The current study investigated whether children with MCDD show the same deficits in sensory gating that are commonly reported in schizophrenia, or whether they are indistinguishable from children with autism in this respect. P50 suppression and prepulse inhibition (PPI) of the startle reflex were assessed in children with MCDD (n=14) or autism (n=13), and healthy controls (n=12), matched on age and IQ. All subjects showed high levels of PPI and P50 suppression. However, no group differences were found. No abnormalities in sensory filtering could be detected in children with autism or MCDD. Since sensory gating deficits are commonly regarded as possible endophenotypic markers for schizophrenia, the current results do not support a high level of similarity between schizophrenia and MCDD. Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",

keywords = "P50 suppression, PPI, Startle reflex",

author = "Bob Oranje and B. Lahuis and {Van Engeland}, H. and {Van der Gaag}, R. and C. Kemner",

year = "2013",

month = apr,

day = "30",

doi = "10.1016/j.psychres.2012.10.014",

language = "English",

volume = "206",

pages = "287--292",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - Sensory and sensorimotor gating in children with multiple complex developmental disorders (MCDD) and autism.

AU - Oranje, Bob

AU - Lahuis, B.

AU - Van Engeland, H.

AU - Van der Gaag, R.

AU - Kemner, C.

PY - 2013/4/30

Y1 - 2013/4/30

N2 - Multiple Complex Developmental Disorder (MCDD) is a well-defined and validated behavioral subtype of autism with a proposed elevated risk of developing a schizophrenic spectrum disorder. The current study investigated whether children with MCDD show the same deficits in sensory gating that are commonly reported in schizophrenia, or whether they are indistinguishable from children with autism in this respect. P50 suppression and prepulse inhibition (PPI) of the startle reflex were assessed in children with MCDD (n=14) or autism (n=13), and healthy controls (n=12), matched on age and IQ. All subjects showed high levels of PPI and P50 suppression. However, no group differences were found. No abnormalities in sensory filtering could be detected in children with autism or MCDD. Since sensory gating deficits are commonly regarded as possible endophenotypic markers for schizophrenia, the current results do not support a high level of similarity between schizophrenia and MCDD. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

AB - Multiple Complex Developmental Disorder (MCDD) is a well-defined and validated behavioral subtype of autism with a proposed elevated risk of developing a schizophrenic spectrum disorder. The current study investigated whether children with MCDD show the same deficits in sensory gating that are commonly reported in schizophrenia, or whether they are indistinguishable from children with autism in this respect. P50 suppression and prepulse inhibition (PPI) of the startle reflex were assessed in children with MCDD (n=14) or autism (n=13), and healthy controls (n=12), matched on age and IQ. All subjects showed high levels of PPI and P50 suppression. However, no group differences were found. No abnormalities in sensory filtering could be detected in children with autism or MCDD. Since sensory gating deficits are commonly regarded as possible endophenotypic markers for schizophrenia, the current results do not support a high level of similarity between schizophrenia and MCDD. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

KW - P50 suppression

KW - PPI

KW - Startle reflex

UR - http://www.scopus.com/inward/record.url?scp=84884188608&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2012.10.014

DO - 10.1016/j.psychres.2012.10.014

M3 - Article

C2 - 23164481

SN - 0165-1781

VL - 206

SP - 287

EP - 292

JO - Psychiatry Research

JF - Psychiatry Research

IS - 2-3

ER -

Sensory and sensorimotor gating in children with multiple complex developmental disorders (MCDD) and autism.

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this