Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

Jyoti Parkash; Andrea Messina; Fanny Langlet; Irene Cimino; Anne Loyens; Danièle Mazur; Sarah Gallet; Eglantine Balland; Samuel A. Malone; François Pralong; Gabriella Cagnoni; Roberta Schellino; Silvia De Marchis; Massimiliano Mazzone; R. Jeroen Pasterkamp; Luca Tamagnone; Vincent Prevot; Paolo Giacobini

doi:10.1038/ncomms7385

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

Jyoti Parkash, Andrea Messina, Fanny Langlet, Irene Cimino, Anne Loyens, Danièle Mazur, Sarah Gallet, Eglantine Balland, Samuel A. Malone, François Pralong, Gabriella Cagnoni, Roberta Schellino, Silvia De Marchis, Massimiliano Mazzone, R. Jeroen Pasterkamp, Luca Tamagnone, Vincent Prevot, Paolo Giacobini^*

^*Corresponding author for this work

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Abstract

Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic-pituitary-gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.

Original language	English
Article number	6385
Journal	Nature Communications [E]
Volume	6
DOIs	https://doi.org/10.1038/ncomms7385
Publication status	Published - 27 Feb 2015

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Parkash, J., Messina, A., Langlet, F., Cimino, I., Loyens, A., Mazur, D., Gallet, S., Balland, E., Malone, S. A., Pralong, F., Cagnoni, G., Schellino, R., De Marchis, S., Mazzone, M., Pasterkamp, R. J., Tamagnone, L., Prevot, V., & Giacobini, P. (2015). Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence. Nature Communications [E], 6, Article 6385. https://doi.org/10.1038/ncomms7385

@article{a0d46529121f42a0964f162ea8e4eb7e,

title = "Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence",

abstract = "Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic-pituitary-gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.",

author = "Jyoti Parkash and Andrea Messina and Fanny Langlet and Irene Cimino and Anne Loyens and Dani{\`e}le Mazur and Sarah Gallet and Eglantine Balland and Malone, {Samuel A.} and Fran{\c c}ois Pralong and Gabriella Cagnoni and Roberta Schellino and {De Marchis}, Silvia and Massimiliano Mazzone and Pasterkamp, {R. Jeroen} and Luca Tamagnone and Vincent Prevot and Paolo Giacobini",

year = "2015",

month = feb,

day = "27",

doi = "10.1038/ncomms7385",

language = "English",

volume = "6",

journal = "Nature Communications [E]",

issn = "2041-1723",

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Parkash, J, Messina, A, Langlet, F, Cimino, I, Loyens, A, Mazur, D, Gallet, S, Balland, E, Malone, SA, Pralong, F, Cagnoni, G, Schellino, R, De Marchis, S, Mazzone, M, Pasterkamp, RJ, Tamagnone, L, Prevot, V & Giacobini, P 2015, 'Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence', Nature Communications [E], vol. 6, 6385. https://doi.org/10.1038/ncomms7385

TY - JOUR

T1 - Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

AU - Parkash, Jyoti

AU - Messina, Andrea

AU - Langlet, Fanny

AU - Cimino, Irene

AU - Loyens, Anne

AU - Mazur, Danièle

AU - Gallet, Sarah

AU - Balland, Eglantine

AU - Malone, Samuel A.

AU - Pralong, François

AU - Cagnoni, Gabriella

AU - Schellino, Roberta

AU - De Marchis, Silvia

AU - Mazzone, Massimiliano

AU - Pasterkamp, R. Jeroen

AU - Tamagnone, Luca

AU - Prevot, Vincent

AU - Giacobini, Paolo

PY - 2015/2/27

Y1 - 2015/2/27

N2 - Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic-pituitary-gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.

AB - Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic-pituitary-gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.

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DO - 10.1038/ncomms7385

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C2 - 25721933

AN - SCOPUS:84924023377

SN - 2041-1723

VL - 6

JO - Nature Communications [E]

JF - Nature Communications [E]

M1 - 6385

ER -

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

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