TY - JOUR
T1 - Semaphorin junction
T2 - Making tracks toward neural connectivity
AU - Pasterkamp, R. Jeroen
AU - Kolodkin, Alex L.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.
AB - Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.
UR - http://www.scopus.com/inward/record.url?scp=0037320703&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(03)00003-5
DO - 10.1016/S0959-4388(03)00003-5
M3 - Review article
C2 - 12593985
AN - SCOPUS:0037320703
SN - 0959-4388
VL - 13
SP - 79
EP - 89
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -