Semaphorin junction: Making tracks toward neural connectivity

R. Jeroen Pasterkamp*, Alex L. Kolodkin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

236 Citations (Scopus)


Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.

Original languageEnglish
Pages (from-to)79-89
Number of pages11
JournalCurrent Opinion in Neurobiology
Issue number1
Publication statusPublished - 1 Jan 2003


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