Selective Arterial Spin Labeling: Techniques and Neurovascular Applications

Reinoud P H Bokkers, Laurens J De Cocker, M J P van Osch, NS Hartkamp, J Hendrikse

Research output: Contribution to journalArticleAcademicpeer-review


Knowledge of the distribution of blood flowing from the heart to the brain-feeding arteries is important for the understanding and diagnosis of cerebrovascular diseases. Due to anatomical variations and anomalies within the cerebrovasculature, together with changes caused by various cerebrovascular diseases, there is high variability in the distribution of blood to the parenchyma. This article reviews the various methods that are available for determining the flow territories of the brain-feeding arteries and provides an overview of the different territorial arterial spin labeling (ASL) magnetic resonance imaging (MRI) techniques that have been introduced during the past 2 decades. ASL is a noninvasive method that uses arterial blood as an endogenous contrast agent by magnetically labeling the inflowing blood with radiofrequency pulses. Several selective ASL MRI methods are available to visualize the perfusion territories of individual brain feeding arteries and determine the presence of collateral blood flow pathways. Clinically, these selective perfusion methods may replace more invasive procedures such as catheter angiography for various diseases in which it is of importance to determine the feeding blood vessels, evaluate the presence potential collateral pathways, and monitor the patency of surgical bypasses.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalTopics in Magnetic Resonance Imaging
Issue number2
Publication statusPublished - Apr 2016


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