Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: A prospective multicenter trial

Asaf Senft; Remco de Bree; Otto S. Hoekstra; Dirk J. Kuik; Richard P. Golding; Wim J.G. Oyen; Jan Pruim; Frank J. van den Hoogen; Jan L.N. Roodenburg; C. René Leemans

doi:10.1016/j.radonc.2008.03.008

Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: A prospective multicenter trial

Asaf Senft
, Remco de Bree^*
, Otto S. Hoekstra
, Dirk J. Kuik
, Richard P. Golding
, Wim J.G. Oyen
, Jan Pruim
, Frank J. van den Hoogen
, Jan L.N. Roodenburg
, C. René Leemans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

78 Citations (Scopus)

Abstract

Background and purpose: The aim of the study was to define the added value of whole body FDG-PET in screening for distant metastases in patients with head and neck squamous cell carcinoma and risk factors. Materials and methods: In a multi-center prospective study between 1998 and 2003, 145 consecutive HNSCC patients with risk factors for distant metastases underwent chest CT and whole body FDG-PET for screening of distant metastases. The data of 92 evaluable patients who developed distant metastases or who had a follow-up of at least 12 months were analyzed. Besides their performance in clinical practice, the operational characteristics of PET and CT using ROC analyses were investigated. Results: Pretreatment screening identified distant metastases in 19 patients (21%). FDG-PET had a higher sensitivity (53% vs. 37%) and positive predictive value (80% vs. 75%) than CT. The combination of CT and FDG-PET had the highest sensitivity (63%). The ROC analyses of the five point ordinal scales revealed that the "area under the curve" (AUC) of FDG-PET was significantly higher as compared to CT. Conclusion: In HNSCC patients with risk factors, pretreatment screening for distant metastases by chest CT is improved by FDG-PET.

Original language	English
Pages (from-to)	221-229
Number of pages	9
Journal	Radiotherapy and Oncology
Volume	87
Issue number	2
DOIs	https://doi.org/10.1016/j.radonc.2008.03.008
Publication status	Published - 1 May 2008

Keywords

CT
Distant metastases
FDG-PET
Head and neck cancer
Screening

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10.1016/j.radonc.2008.03.008

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Senft, A., de Bree, R., Hoekstra, O. S., Kuik, D. J., Golding, R. P., Oyen, W. J. G., Pruim, J., van den Hoogen, F. J., Roodenburg, J. L. N., & Leemans, C. R. (2008). Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: A prospective multicenter trial. Radiotherapy and Oncology, 87(2), 221-229. https://doi.org/10.1016/j.radonc.2008.03.008

@article{62a15427dee94109ad7400bb97d584cb,

title = "Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: A prospective multicenter trial",

abstract = "Background and purpose: The aim of the study was to define the added value of whole body FDG-PET in screening for distant metastases in patients with head and neck squamous cell carcinoma and risk factors. Materials and methods: In a multi-center prospective study between 1998 and 2003, 145 consecutive HNSCC patients with risk factors for distant metastases underwent chest CT and whole body FDG-PET for screening of distant metastases. The data of 92 evaluable patients who developed distant metastases or who had a follow-up of at least 12 months were analyzed. Besides their performance in clinical practice, the operational characteristics of PET and CT using ROC analyses were investigated. Results: Pretreatment screening identified distant metastases in 19 patients (21\%). FDG-PET had a higher sensitivity (53\% vs. 37\%) and positive predictive value (80\% vs. 75\%) than CT. The combination of CT and FDG-PET had the highest sensitivity (63\%). The ROC analyses of the five point ordinal scales revealed that the {"}area under the curve{"} (AUC) of FDG-PET was significantly higher as compared to CT. Conclusion: In HNSCC patients with risk factors, pretreatment screening for distant metastases by chest CT is improved by FDG-PET.",

keywords = "CT, Distant metastases, FDG-PET, Head and neck cancer, Screening",

author = "Asaf Senft and \{de Bree\}, Remco and Hoekstra, \{Otto S.\} and Kuik, \{Dirk J.\} and Golding, \{Richard P.\} and Oyen, \{Wim J.G.\} and Jan Pruim and \{van den Hoogen\}, \{Frank J.\} and Roodenburg, \{Jan L.N.\} and Leemans, \{C. Ren{\'e}\}",

year = "2008",

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doi = "10.1016/j.radonc.2008.03.008",

language = "English",

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issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

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Senft, A, de Bree, R, Hoekstra, OS, Kuik, DJ, Golding, RP, Oyen, WJG, Pruim, J, van den Hoogen, FJ, Roodenburg, JLN & Leemans, CR 2008, 'Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: A prospective multicenter trial', Radiotherapy and Oncology, vol. 87, no. 2, pp. 221-229. https://doi.org/10.1016/j.radonc.2008.03.008

TY - JOUR

T1 - Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET

T2 - A prospective multicenter trial

AU - Senft, Asaf

AU - de Bree, Remco

AU - Hoekstra, Otto S.

AU - Kuik, Dirk J.

AU - Golding, Richard P.

AU - Oyen, Wim J.G.

AU - Pruim, Jan

AU - van den Hoogen, Frank J.

AU - Roodenburg, Jan L.N.

AU - Leemans, C. René

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Background and purpose: The aim of the study was to define the added value of whole body FDG-PET in screening for distant metastases in patients with head and neck squamous cell carcinoma and risk factors. Materials and methods: In a multi-center prospective study between 1998 and 2003, 145 consecutive HNSCC patients with risk factors for distant metastases underwent chest CT and whole body FDG-PET for screening of distant metastases. The data of 92 evaluable patients who developed distant metastases or who had a follow-up of at least 12 months were analyzed. Besides their performance in clinical practice, the operational characteristics of PET and CT using ROC analyses were investigated. Results: Pretreatment screening identified distant metastases in 19 patients (21%). FDG-PET had a higher sensitivity (53% vs. 37%) and positive predictive value (80% vs. 75%) than CT. The combination of CT and FDG-PET had the highest sensitivity (63%). The ROC analyses of the five point ordinal scales revealed that the "area under the curve" (AUC) of FDG-PET was significantly higher as compared to CT. Conclusion: In HNSCC patients with risk factors, pretreatment screening for distant metastases by chest CT is improved by FDG-PET.

AB - Background and purpose: The aim of the study was to define the added value of whole body FDG-PET in screening for distant metastases in patients with head and neck squamous cell carcinoma and risk factors. Materials and methods: In a multi-center prospective study between 1998 and 2003, 145 consecutive HNSCC patients with risk factors for distant metastases underwent chest CT and whole body FDG-PET for screening of distant metastases. The data of 92 evaluable patients who developed distant metastases or who had a follow-up of at least 12 months were analyzed. Besides their performance in clinical practice, the operational characteristics of PET and CT using ROC analyses were investigated. Results: Pretreatment screening identified distant metastases in 19 patients (21%). FDG-PET had a higher sensitivity (53% vs. 37%) and positive predictive value (80% vs. 75%) than CT. The combination of CT and FDG-PET had the highest sensitivity (63%). The ROC analyses of the five point ordinal scales revealed that the "area under the curve" (AUC) of FDG-PET was significantly higher as compared to CT. Conclusion: In HNSCC patients with risk factors, pretreatment screening for distant metastases by chest CT is improved by FDG-PET.

KW - CT

KW - Distant metastases

KW - FDG-PET

KW - Head and neck cancer

KW - Screening

UR - https://www.scopus.com/pages/publications/43049176665

U2 - 10.1016/j.radonc.2008.03.008

DO - 10.1016/j.radonc.2008.03.008

M3 - Article

C2 - 18410977

AN - SCOPUS:43049176665

SN - 0167-8140

VL - 87

SP - 221

EP - 229

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 2

ER -

Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: A prospective multicenter trial

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Keywords

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