Schistosome biology and proteomics: Progress and challenges

Jaap J. van Hellemond*, Bas W M van Balkom, Aloysius G M Tielens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

The recent availability of schistosomal genome-sequence information allows protein identification in schistosome-derived samples by mass spectrometry (proteomics). Over the last few years, several proteome studies have been performed that addressed important questions in schistosome biology. This review summarizes the applied experimental approaches that have been used so far, it provides an overview of the most important conclusions that can be drawn from the performed studies and finally discusses future challenges in this research area.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalExperimental Parasitology
Volume117
Issue number3
DOIs
Publication statusPublished - 1 Nov 2007

Keywords

  • electrospray ionisation
  • ESI
  • Host-parasite interaction
  • MALDI
  • mass spectrometry
  • matrix assisted laser desorption ionization
  • MS
  • Proteome
  • SDS-PAGE
  • sodium dodecyl sulfate-polyacrylamide gelelectrophoresis
  • Tegument
  • time-of-flight
  • TOF

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