Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor: two case reports

P. van Mourik; E. C. van der Hout; H. D. Luijk; R. W. Hofland; A. H.W. Bruns; H. G.M. Heijerman; I. Bronsveld

doi:10.1016/j.rmcr.2025.102278

Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor: two case reports

P. van Mourik^*
, E. C. van der Hout
, H. D. Luijk
, R. W. Hofland
, A. H.W. Bruns
, H. G.M. Heijerman
, I. Bronsveld

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Highly effective modulator treatment (HEMT) has resulted in an improved prognosis for people with cystic fibrosis (pwCF). In this case report, we present two pwCF with clinical stabilization after start of HEMT who developed complicated fungal infections after several years of clinical stability, highlighting the importance of continued careful monitoring of pwCF on HEMT and considering early antifungal treatment in this population.

Original language	English
Article number	102278
Journal	Respiratory Medicine Case Reports
Volume	57
DOIs	https://doi.org/10.1016/j.rmcr.2025.102278
Publication status	Published - Jan 2025

Keywords

Cystic fibrosis
Elexacaftor/tezacaftor/ivacaftor
Scedosporium

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10.1016/j.rmcr.2025.102278Licence: CC BY

1-s2.0-S2213007125001145-mainFinal published version, 1.01 MBLicence: CC BY

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title = "Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor: two case reports",

abstract = "Highly effective modulator treatment (HEMT) has resulted in an improved prognosis for people with cystic fibrosis (pwCF). In this case report, we present two pwCF with clinical stabilization after start of HEMT who developed complicated fungal infections after several years of clinical stability, highlighting the importance of continued careful monitoring of pwCF on HEMT and considering early antifungal treatment in this population.",

keywords = "Cystic fibrosis, Elexacaftor/tezacaftor/ivacaftor, Scedosporium",

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note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = jan,

doi = "10.1016/j.rmcr.2025.102278",

language = "English",

volume = "57",

journal = "Respiratory Medicine Case Reports",

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T1 - Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor

T2 - two case reports

AU - van Mourik, P.

AU - van der Hout, E. C.

AU - Luijk, H. D.

AU - Hofland, R. W.

AU - Bruns, A. H.W.

AU - Heijerman, H. G.M.

AU - Bronsveld, I.

PY - 2025/1

Y1 - 2025/1

N2 - Highly effective modulator treatment (HEMT) has resulted in an improved prognosis for people with cystic fibrosis (pwCF). In this case report, we present two pwCF with clinical stabilization after start of HEMT who developed complicated fungal infections after several years of clinical stability, highlighting the importance of continued careful monitoring of pwCF on HEMT and considering early antifungal treatment in this population.

AB - Highly effective modulator treatment (HEMT) has resulted in an improved prognosis for people with cystic fibrosis (pwCF). In this case report, we present two pwCF with clinical stabilization after start of HEMT who developed complicated fungal infections after several years of clinical stability, highlighting the importance of continued careful monitoring of pwCF on HEMT and considering early antifungal treatment in this population.

KW - Cystic fibrosis

KW - Elexacaftor/tezacaftor/ivacaftor

KW - Scedosporium

UR - https://www.scopus.com/pages/publications/105014610363

U2 - 10.1016/j.rmcr.2025.102278

DO - 10.1016/j.rmcr.2025.102278

M3 - Article

C2 - 40979741

AN - SCOPUS:105014610363

VL - 57

JO - Respiratory Medicine Case Reports

JF - Respiratory Medicine Case Reports

M1 - 102278

ER -

Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor: two case reports

Abstract

Keywords

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