SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Giuseppe De Luca; Magdy Algowhary; Berat Uguz; Dinaldo C. Oliveira; Vladimir Ganyukov; Zan Zimbakov; Miha Cercek; Lisette Okkels Jensen; Poay Huan Loh; Lucian Calmac; Gerard Roura i Ferrer; Alexandre Quadros; Marek Milewski; Fortunato Scotto Di Uccio; Clemens von Birgelen; Francesco Versaci; Jurrien Ten Berg; Gianni Casella; Aaron Wong Sung Lung; Petr Kala; José Luis Díez Gil; Xavier Carrillo; Maurits Dirksen; Victor M. Becerra-Munoz; Michael Kang-yin Lee; Dafsah Arifa Juzar; Rodrigo de Moura Joaquim; Ciro De Simone; Davor Milicic; Periklis Davlouros; Nikola Bakraceski; Filippo Zilio; Luca Donazzan; Adriaan Kraaijeveld; Gennaro Galasso; Lux Arpad; Lucia Marinucci; Vincenzo Guiducci; Maurizio Menichelli; Alessandra Scoccia; Aylin Hatice Yamac; Kadir Ugur Mert; Xacobe Flores Rios; Tomas Kovarnik; Michal Kidawa; Josè Moreu; Vincent Flavien; Enrico Fabris; Iñigo Lozano Martínez-Luengas; Marco Boccalatte; Francisco Bosa Ojeda; Carlos Arellano-Serrano; Gianluca Caiazzo; Giuseppe Cirrincione; Hsien Li Kao; Juan Sanchis Forés; Luigi Vignali; Helder Pereira; Stephane Manzo-Silbermann; Santiago Ordoñez; Alev Arat Özkan; Bruno Scheller; Heidi Lehtola; Rui Teles; Christos Mantis; Ylitalo Antti; João António Brum Silveira; Ivan Bessonov; Rodrigo Zoni; Stefano Savonitto; George Kochiadakis; Dimitrios Alexopoulos; Carlos E. Uribe; John Kanakakis; Benjamin Faurie; Gabriele Gabrielli; Alejandro Gutierrez Barrios; Juan Pablo Bachini; Alex Rocha; Frankie Chor Cheung Tam; Alfredo Rodriguez; Antonia Anna Lukito; Anne Bellemain-Appaix; Gustavo Pessah; Giuliana Cortese; Guido Parodi; Mohammed Abed Burgadha; Elvin Kedhi; Pablo Lamelas; Harry Suryapranata; Matteo Nardin; Monica Verdoia

doi:10.1177/00033197221129351

SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Giuseppe De Luca^*, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura i Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto Di Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr KalaJosé Luis Díez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Ciro De Simone, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Lucia Marinucci, Vincenzo Guiducci, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Josè Moreu, Vincent Flavien, Enrico Fabris, Iñigo Lozano Martínez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien Li Kao, Juan Sanchis Forés, Luigi Vignali, Helder Pereira, Stephane Manzo-Silbermann, Santiago Ordoñez, Alev Arat Özkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, João António Brum Silveira, Ivan Bessonov, Rodrigo Zoni, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopoulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Anne Bellemain-Appaix, Gustavo Pessah, Giuliana Cortese, Guido Parodi, Mohammed Abed Burgadha, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P =.002), less often active smokers (P =.002), and hypercholesterolemic (P =.006), they presented more often later than 12 h (P =.037), more often to the hub and were more often in cardiogenic shock (P =.02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P <.0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P =.029) and more thrombectomy (P =.046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P <.001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P <.001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P <.001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.

Original language	English
Pages (from-to)	987-996
Number of pages	10
Journal	Angiology
Volume	74
Issue number	10
DOIs	https://doi.org/10.1177/00033197221129351
Publication status	Published - 1 Nov 2023

Keywords

outcome
STEMI
thrombosis

Access to Document

10.1177/00033197221129351

Cite this

De Luca, G., Algowhary, M., Uguz, B., Oliveira, D. C., Ganyukov, V., Zimbakov, Z., Cercek, M., Okkels Jensen, L., Loh, P. H., Calmac, L., Roura i Ferrer, G., Quadros, A., Milewski, M., Scotto Di Uccio, F., von Birgelen, C., Versaci, F., Ten Berg, J., Casella, G., Wong Sung Lung, A., ... Verdoia, M. (2023). SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion. Angiology, 74(10), 987-996. https://doi.org/10.1177/00033197221129351

@article{fb81235ae8374553aea2fbf7ee060d01,

title = "SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion",

abstract = "SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P =.002), less often active smokers (P =.002), and hypercholesterolemic (P =.006), they presented more often later than 12 h (P =.037), more often to the hub and were more often in cardiogenic shock (P =.02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P <.0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P =.029) and more thrombectomy (P =.046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P <.001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P <.001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P <.001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.",

keywords = "outcome, STEMI, thrombosis",

author = "{De Luca}, Giuseppe and Magdy Algowhary and Berat Uguz and Oliveira, {Dinaldo C.} and Vladimir Ganyukov and Zan Zimbakov and Miha Cercek and {Okkels Jensen}, Lisette and Loh, {Poay Huan} and Lucian Calmac and {Roura i Ferrer}, Gerard and Alexandre Quadros and Marek Milewski and {Scotto Di Uccio}, Fortunato and {von Birgelen}, Clemens and Francesco Versaci and {Ten Berg}, Jurrien and Gianni Casella and {Wong Sung Lung}, Aaron and Petr Kala and {D{\'i}ez Gil}, {Jos{\'e} Luis} and Xavier Carrillo and Maurits Dirksen and Becerra-Munoz, {Victor M.} and {Kang-yin Lee}, Michael and Juzar, {Dafsah Arifa} and {de Moura Joaquim}, Rodrigo and {De Simone}, Ciro and Davor Milicic and Periklis Davlouros and Nikola Bakraceski and Filippo Zilio and Luca Donazzan and Adriaan Kraaijeveld and Gennaro Galasso and Lux Arpad and Lucia Marinucci and Vincenzo Guiducci and Maurizio Menichelli and Alessandra Scoccia and Yamac, {Aylin Hatice} and {Ugur Mert}, Kadir and {Flores Rios}, Xacobe and Tomas Kovarnik and Michal Kidawa and Jos{\`e} Moreu and Vincent Flavien and Enrico Fabris and {Lozano Mart{\'i}nez-Luengas}, I{\~n}igo and Marco Boccalatte and {Bosa Ojeda}, Francisco and Carlos Arellano-Serrano and Gianluca Caiazzo and Giuseppe Cirrincione and Kao, {Hsien Li} and {Sanchis For{\'e}s}, Juan and Luigi Vignali and Helder Pereira and Stephane Manzo-Silbermann and Santiago Ordo{\~n}ez and {Arat {\"O}zkan}, Alev and Bruno Scheller and Heidi Lehtola and Rui Teles and Christos Mantis and Ylitalo Antti and {Brum Silveira}, {Jo{\~a}o Ant{\'o}nio} and Ivan Bessonov and Rodrigo Zoni and Stefano Savonitto and George Kochiadakis and Dimitrios Alexopoulos and Uribe, {Carlos E.} and John Kanakakis and Benjamin Faurie and Gabriele Gabrielli and {Gutierrez Barrios}, Alejandro and Bachini, {Juan Pablo} and Alex Rocha and Tam, {Frankie Chor Cheung} and Alfredo Rodriguez and Lukito, {Antonia Anna} and Anne Bellemain-Appaix and Gustavo Pessah and Giuliana Cortese and Guido Parodi and Burgadha, {Mohammed Abed} and Elvin Kedhi and Pablo Lamelas and Harry Suryapranata and Matteo Nardin and Monica Verdoia",

note = "Funding Information: The study was promoted by the Eastern Piedmont University, Novara, Italy, without any financial support. Clinical Trials.gov Identifier, NCT04412655. Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2023",

month = nov,

day = "1",

doi = "10.1177/00033197221129351",

language = "English",

volume = "74",

pages = "987--996",

journal = "Angiology",

issn = "0003-3197",

publisher = "SAGE Publications Inc.",

number = "10",

}

De Luca, G, Algowhary, M, Uguz, B, Oliveira, DC, Ganyukov, V, Zimbakov, Z, Cercek, M, Okkels Jensen, L, Loh, PH, Calmac, L, Roura i Ferrer, G, Quadros, A, Milewski, M, Scotto Di Uccio, F, von Birgelen, C, Versaci, F, Ten Berg, J, Casella, G, Wong Sung Lung, A, Kala, P, Díez Gil, JL, Carrillo, X, Dirksen, M, Becerra-Munoz, VM, Kang-yin Lee, M, Juzar, DA, de Moura Joaquim, R, De Simone, C, Milicic, D, Davlouros, P, Bakraceski, N, Zilio, F, Donazzan, L, Kraaijeveld, A, Galasso, G, Arpad, L, Marinucci, L, Guiducci, V, Menichelli, M, Scoccia, A, Yamac, AH, Ugur Mert, K, Flores Rios, X, Kovarnik, T, Kidawa, M, Moreu, J, Flavien, V, Fabris, E, Lozano Martínez-Luengas, I, Boccalatte, M, Bosa Ojeda, F, Arellano-Serrano, C, Caiazzo, G, Cirrincione, G, Kao, HL, Sanchis Forés, J, Vignali, L, Pereira, H, Manzo-Silbermann, S, Ordoñez, S, Arat Özkan, A, Scheller, B, Lehtola, H, Teles, R, Mantis, C, Antti, Y, Brum Silveira, JA, Bessonov, I, Zoni, R, Savonitto, S, Kochiadakis, G, Alexopoulos, D, Uribe, CE, Kanakakis, J, Faurie, B, Gabrielli, G, Gutierrez Barrios, A, Bachini, JP, Rocha, A, Tam, FCC, Rodriguez, A, Lukito, AA, Bellemain-Appaix, A, Pessah, G, Cortese, G, Parodi, G, Burgadha, MA, Kedhi, E, Lamelas, P, Suryapranata, H, Nardin, M & Verdoia, M 2023, 'SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion', Angiology, vol. 74, no. 10, pp. 987-996. https://doi.org/10.1177/00033197221129351

TY - JOUR

T1 - SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

AU - De Luca, Giuseppe

AU - Algowhary, Magdy

AU - Uguz, Berat

AU - Oliveira, Dinaldo C.

AU - Ganyukov, Vladimir

AU - Zimbakov, Zan

AU - Cercek, Miha

AU - Okkels Jensen, Lisette

AU - Loh, Poay Huan

AU - Calmac, Lucian

AU - Roura i Ferrer, Gerard

AU - Quadros, Alexandre

AU - Milewski, Marek

AU - Scotto Di Uccio, Fortunato

AU - von Birgelen, Clemens

AU - Versaci, Francesco

AU - Ten Berg, Jurrien

AU - Casella, Gianni

AU - Wong Sung Lung, Aaron

AU - Kala, Petr

AU - Díez Gil, José Luis

AU - Carrillo, Xavier

AU - Dirksen, Maurits

AU - Becerra-Munoz, Victor M.

AU - Kang-yin Lee, Michael

AU - Juzar, Dafsah Arifa

AU - de Moura Joaquim, Rodrigo

AU - De Simone, Ciro

AU - Milicic, Davor

AU - Davlouros, Periklis

AU - Bakraceski, Nikola

AU - Zilio, Filippo

AU - Donazzan, Luca

AU - Kraaijeveld, Adriaan

AU - Galasso, Gennaro

AU - Arpad, Lux

AU - Marinucci, Lucia

AU - Guiducci, Vincenzo

AU - Menichelli, Maurizio

AU - Scoccia, Alessandra

AU - Yamac, Aylin Hatice

AU - Ugur Mert, Kadir

AU - Flores Rios, Xacobe

AU - Kovarnik, Tomas

AU - Kidawa, Michal

AU - Moreu, Josè

AU - Flavien, Vincent

AU - Fabris, Enrico

AU - Lozano Martínez-Luengas, Iñigo

AU - Boccalatte, Marco

AU - Bosa Ojeda, Francisco

AU - Arellano-Serrano, Carlos

AU - Caiazzo, Gianluca

AU - Cirrincione, Giuseppe

AU - Kao, Hsien Li

AU - Sanchis Forés, Juan

AU - Vignali, Luigi

AU - Pereira, Helder

AU - Manzo-Silbermann, Stephane

AU - Ordoñez, Santiago

AU - Arat Özkan, Alev

AU - Scheller, Bruno

AU - Lehtola, Heidi

AU - Teles, Rui

AU - Mantis, Christos

AU - Antti, Ylitalo

AU - Brum Silveira, João António

AU - Bessonov, Ivan

AU - Zoni, Rodrigo

AU - Savonitto, Stefano

AU - Kochiadakis, George

AU - Alexopoulos, Dimitrios

AU - Uribe, Carlos E.

AU - Kanakakis, John

AU - Faurie, Benjamin

AU - Gabrielli, Gabriele

AU - Gutierrez Barrios, Alejandro

AU - Bachini, Juan Pablo

AU - Rocha, Alex

AU - Tam, Frankie Chor Cheung

AU - Rodriguez, Alfredo

AU - Lukito, Antonia Anna

AU - Bellemain-Appaix, Anne

AU - Pessah, Gustavo

AU - Cortese, Giuliana

AU - Parodi, Guido

AU - Burgadha, Mohammed Abed

AU - Kedhi, Elvin

AU - Lamelas, Pablo

AU - Suryapranata, Harry

AU - Nardin, Matteo

AU - Verdoia, Monica

N1 - Funding Information: The study was promoted by the Eastern Piedmont University, Novara, Italy, without any financial support. Clinical Trials.gov Identifier, NCT04412655. Publisher Copyright: © The Author(s) 2022.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P =.002), less often active smokers (P =.002), and hypercholesterolemic (P =.006), they presented more often later than 12 h (P =.037), more often to the hub and were more often in cardiogenic shock (P =.02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P <.0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P =.029) and more thrombectomy (P =.046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P <.001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P <.001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P <.001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.

AB - SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P =.002), less often active smokers (P =.002), and hypercholesterolemic (P =.006), they presented more often later than 12 h (P =.037), more often to the hub and were more often in cardiogenic shock (P =.02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P <.0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P =.029) and more thrombectomy (P =.046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P <.001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P <.001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P <.001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.

KW - outcome

KW - STEMI

KW - thrombosis

UR - http://www.scopus.com/inward/record.url?scp=85144019096&partnerID=8YFLogxK

U2 - 10.1177/00033197221129351

DO - 10.1177/00033197221129351

M3 - Article

C2 - 36222189

AN - SCOPUS:85144019096

SN - 0003-3197

VL - 74

SP - 987

EP - 996

JO - Angiology

JF - Angiology

IS - 10

ER -

SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this