Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide

Daniel H van Raalte; Susan M Goorden; Evelien A Kemper; Lodewijk A A Brosens; Reinier W ten Kate

doi:10.1136/bcr-2015-210189

Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide

Daniel H van Raalte, Susan M Goorden, Evelien A Kemper, Lodewijk A A Brosens, Reinier W ten Kate

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis.

Original language	English
Journal	BMJ Case Reports [E]
Volume	2015
DOIs	https://doi.org/10.1136/bcr-2015-210189
Publication status	Published - 2015

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title = "Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide",

abstract = "Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis.",

author = "{van Raalte}, {Daniel H} and Goorden, {Susan M} and Kemper, {Evelien A} and Brosens, {Lodewijk A A} and {ten Kate}, {Reinier W}",

note = "2015 BMJ Publishing Group Ltd.",

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language = "English",

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T1 - Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide

AU - van Raalte, Daniel H

AU - Goorden, Susan M

AU - Kemper, Evelien A

AU - Brosens, Lodewijk A A

AU - ten Kate, Reinier W

N1 - 2015 BMJ Publishing Group Ltd.

PY - 2015

Y1 - 2015

N2 - Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis.

AB - Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis.

U2 - 10.1136/bcr-2015-210189

DO - 10.1136/bcr-2015-210189

M3 - Article

C2 - 26160550

SN - 1757-790X

VL - 2015

JO - BMJ Case Reports [E]

JF - BMJ Case Reports [E]

ER -

Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide

Abstract

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