Running GAGs: Myxoid matrix in tumor pathology revisited: What's in it for the pathologist

Stefan M. Willems, Malgorzata Wiweger, J. Frans Graadt Van Roggen, Pancras C W Hogendoorn

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


Ever since Virchow introduced the entity myxoma, abundant myxoid extracellular matrix (ECM) has been recognized in various reactive and neoplastic lesions. Nowadays, the term "myxoid" is commonly used in daily pathological practice. But what do today's pathologists mean by it, and what does the myxoid ECM tell the pathologist? What is known about the exact composition and function of the myxoid ECM 150 years after Virchow? Here, we give an overview of the composition and constituents of the myxoid ECM as known so far and demonstrate the heterogeneity of the myxoid ECM among different tumors. We discuss the possible role of the predominant constituents of the myxoid ECM and attempt to relate them to differences in clinical behavior. Finally, we will speculate on the potential relevance of this knowledge in daily pathological practice.

Original languageEnglish
Pages (from-to)181-192
Number of pages12
JournalVirchows Archiv
Issue number2
Publication statusPublished - 1 Feb 2010


  • Collagen
  • Extracellular matrix
  • Glycosaminoglycans
  • Intramuscular myxoma
  • Myxofibrosarcoma
  • Proteoglycan


Dive into the research topics of 'Running GAGs: Myxoid matrix in tumor pathology revisited: What's in it for the pathologist'. Together they form a unique fingerprint.

Cite this