Role of granzymes in cancer development, immunoregulation, and immunotherapy

Shuang Li

doi:10.33540/1298

Role of granzymes in cancer development, immunoregulation, and immunotherapy

Shuang Li

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

The killing potential and relative contribution of all granzymes in tumor elimination during immunotherapy as well as the extracellular roles of tumor microenvironment-associated granzymes in tumorigenesis and cancer immunity largely remain unclear. Knowledge on these issues may not only unravel novel mechanistic insights, but also may open new cancer (immuno)therapeutic avenues. In this thesis, we aim to investigate the roles of intracellular and extracellular granzymes in tumor elimination, tumor progression, and tumor immunity.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Bovenschen, Niels, Primary supervisor Goldschmeding, Roel, Supervisor
Award date	28 Jun 2022
Publisher	Utrecht University
Print ISBNs	978-90-393-7485-6
DOIs	https://doi.org/10.33540/1298
Publication status	Published - 28 Jun 2022

Keywords

granzymes
cancer
immunotherapy
immune checkpoint
medulloblastoma
angioginesis
B7-H3
PD-1/PD-L1

Access to Document

10.33540/1298

https://dspace.library.uu.nl/handle/1874/421367

Embargoed Document

13546completed with cover - 62c2e3408d60b
Final published version, 13.8 MB
Embargo ends: 22/06/27

Cite this

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title = "Role of granzymes in cancer development, immunoregulation, and immunotherapy",

abstract = "The killing potential and relative contribution of all granzymes in tumor elimination during immunotherapy as well as the extracellular roles of tumor microenvironment-associated granzymes in tumorigenesis and cancer immunity largely remain unclear. Knowledge on these issues may not only unravel novel mechanistic insights, but also may open new cancer (immuno)therapeutic avenues. In this thesis, we aim to investigate the roles of intracellular and extracellular granzymes in tumor elimination, tumor progression, and tumor immunity.",

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AB - The killing potential and relative contribution of all granzymes in tumor elimination during immunotherapy as well as the extracellular roles of tumor microenvironment-associated granzymes in tumorigenesis and cancer immunity largely remain unclear. Knowledge on these issues may not only unravel novel mechanistic insights, but also may open new cancer (immuno)therapeutic avenues. In this thesis, we aim to investigate the roles of intracellular and extracellular granzymes in tumor elimination, tumor progression, and tumor immunity.

KW - granzymes

KW - cancer

KW - immunotherapy

KW - immune checkpoint

KW - medulloblastoma

KW - angioginesis

KW - B7-H3

KW - PD-1/PD-L1

U2 - 10.33540/1298

DO - 10.33540/1298

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-90-393-7485-6

PB - Utrecht University

ER -

Role of granzymes in cancer development, immunoregulation, and immunotherapy

Abstract

Keywords

Access to Document

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Cite this