RNA interference mechanisms and therapeutic applications

Anne E. Lamers; Dominique P.V. De Kleijn

doi:10.1007/0-387-23329-6_7

RNA interference mechanisms and therapeutic applications

Anne E. Lamers
, Dominique P.V. De Kleijn

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

RNA interference (RNAi) is a technology developed after the recent discovery of well-conserved cellular processes that induce posttranscriptional gene silencing triggered by small fragments of double-stranded RNA. This technique is rapidly developing into a promising tool used for functional genetics and therapeutic applications. We focus here on the aspects concerning RNAi mechanism, applications in mammals, and construct design and delivery. We summarize some therapeutic applications in general and speculate on the relevance in cardiovascular medicine.

Original language	English
Title of host publication	Cardiovascular Research
Subtitle of host publication	New Technologies, Methods, and Applications
Publisher	Springer
Pages	121-130
Number of pages	10
ISBN (Electronic)	978-0-387-23329-1
ISBN (Print)	978-0-387-23328-4
DOIs	https://doi.org/10.1007/0-387-23329-6_7
Publication status	Published - 2006

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title = "RNA interference mechanisms and therapeutic applications",

abstract = "RNA interference (RNAi) is a technology developed after the recent discovery of well-conserved cellular processes that induce posttranscriptional gene silencing triggered by small fragments of double-stranded RNA. This technique is rapidly developing into a promising tool used for functional genetics and therapeutic applications. We focus here on the aspects concerning RNAi mechanism, applications in mammals, and construct design and delivery. We summarize some therapeutic applications in general and speculate on the relevance in cardiovascular medicine.",

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AB - RNA interference (RNAi) is a technology developed after the recent discovery of well-conserved cellular processes that induce posttranscriptional gene silencing triggered by small fragments of double-stranded RNA. This technique is rapidly developing into a promising tool used for functional genetics and therapeutic applications. We focus here on the aspects concerning RNAi mechanism, applications in mammals, and construct design and delivery. We summarize some therapeutic applications in general and speculate on the relevance in cardiovascular medicine.

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DO - 10.1007/0-387-23329-6_7

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SP - 121

EP - 130

BT - Cardiovascular Research

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ER -

RNA interference mechanisms and therapeutic applications

Abstract

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