RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.

C.M. Cruciat; C. Dolde; R.E.A. de Groot; B. Ohkawara; C. Reinhard; H.C. Korswagen; C. Niehrs

RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.

Translated title of the contribution: RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.

C.M. Cruciat, C. Dolde, R.E.A. de Groot, B. Ohkawara, C. Reinhard, H.C. Korswagen, C. Niehrs

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-beta-catenin network, where it acts as a regulatory subunit of CK1epsilon: In a Wnt-dependent manner, DDX3 binds CK1epsilon and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-beta-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.

Translated title of the contribution	RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.
Original language	Undefined/Unknown
Pages (from-to)	1436-41
Number of pages	6
Journal	Science
Volume	339
Issue number	6126
Publication status	Published - 2013

Cite this

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title = "RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.",

abstract = "Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered {"}rogue{"} kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-beta-catenin network, where it acts as a regulatory subunit of CK1epsilon: In a Wnt-dependent manner, DDX3 binds CK1epsilon and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-beta-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.",

author = "C.M. Cruciat and C. Dolde and {de Groot}, R.E.A. and B. Ohkawara and C. Reinhard and H.C. Korswagen and C. Niehrs",

year = "2013",

language = "Undefined/Unknown",

volume = "339",

pages = "1436--41",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.

AU - Cruciat, C.M.

AU - Dolde, C.

AU - de Groot, R.E.A.

AU - Ohkawara, B.

AU - Reinhard, C.

AU - Korswagen, H.C.

AU - Niehrs, C.

PY - 2013

Y1 - 2013

N2 - Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-beta-catenin network, where it acts as a regulatory subunit of CK1epsilon: In a Wnt-dependent manner, DDX3 binds CK1epsilon and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-beta-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.

AB - Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-beta-catenin network, where it acts as a regulatory subunit of CK1epsilon: In a Wnt-dependent manner, DDX3 binds CK1epsilon and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-beta-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.

M3 - Article

SN - 0036-8075

VL - 339

SP - 1436

EP - 1441

JO - Science

JF - Science

IS - 6126

ER -

RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.

Abstract

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