TY - JOUR
T1 - Risk of cataract and glaucoma in patients with multiple sclerosis
AU - Bazelier, Marloes T.
AU - Mueller-Schotte, Sigrid
AU - Leufkens, Hubert Gm
AU - Uitdehaag, Bernard Mj
AU - Van Staa, Tjeerd
AU - De Vries, Frank
N1 - Funding Information:
The Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, employing authors Marloes Bazelier, Hubert Leufkens, Tjeerd van Staa and Frank de Vries has received unrestricted funding for pharmacoepidemiological research from GlaxoSmithKline, Novo Nordisk, private–public funded Top Institute Pharma ( www.tipharma.nl and includes co-funding from universities, government and industry), the Dutch Medicines Evaluation Board and the Dutch Ministry of Health.
Funding Information:
Tjeerd van Staa also works for the General Practice Research Database (GPRD). GPRD is owned by the UK Department of Health and operates within the Medicines and Healthcare products Regulatory Agency (MHRA). GPRD is funded by the MHRA, Medical Research Council, various universities, contract research organizations and pharmaceutical companies. The views expressed in this paper are those of the authors and do not reflect the official policy or position of the Medicines and Healthcare products Regulatory Agency, UK.
Funding Information:
This study has been funded with Dr de Vries’ career establishment grant from the European Calcified Tissue Society.
PY - 2012/5
Y1 - 2012/5
N2 - Background: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.Methods: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.Results: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93). Conclusion: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.
AB - Background: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.Methods: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.Results: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93). Conclusion: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.
KW - cataract
KW - epidemiology
KW - glaucoma
KW - glucocorticoids
KW - multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=84860466857&partnerID=8YFLogxK
U2 - 10.1177/1352458511426737
DO - 10.1177/1352458511426737
M3 - Article
AN - SCOPUS:84860466857
SN - 1352-4585
VL - 18
SP - 628
EP - 638
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 5
ER -