Risk factors for lobar and non-lobar intracerebral hemorrhage in patients with vascular disease

Philip H C Kremer; Wilmar M T Jolink; L. Jaap Kappelle; Ale Algra; Catharina J M Klijn; Y. Van Der Graaf; D. E. Grobbee; G. E H M Rutten; F. L J Visseren; F. L. Moll; L. J. Kappelle; W. P T M Mali; P. A. Doevendans; P. H A Halkes; J. Van Gijn; L. J. Kappelle; P. J. Koudstaal

doi:10.1371/journal.pone.0142338

Risk factors for lobar and non-lobar intracerebral hemorrhage in patients with vascular disease

Philip H C Kremer, Wilmar M T Jolink, L. Jaap Kappelle, Ale Algra, Catharina J M Klijn, Y. Van Der Graaf, D. E. Grobbee, G. E H M Rutten, F. L J Visseren, F. L. Moll, L. J. Kappelle, W. P T M Mali, P. A. Doevendans, P. H A Halkes, J. Van Gijn, L. J. Kappelle, P. J. Koudstaal

Research output: Contribution to journal › Article › Academic › peer-review

1 Downloads (Pure)

Abstract

INTRODUCTION: Lobar and non-lobar non-traumatic intracerebral hemorrhage (ICH) are presumably caused by different types of small vessel diseases. The aim of this study was to assess risk factors for ICH according to location.

METHODS: In two large prospective studies, SMART (n = 9088) and ESPRIT (n = 2625), including patients with manifest cardiovascular, cerebrovascular or peripheral artery disease or with vascular risk factors, we investigated potential risk factors for ICH during follow-up according to lobar or non-lobar location by Cox proportional hazards analyses.

RESULTS: During 65,156 patient years of follow up 19 patients had lobar ICH (incidence rate 29, 95% CI 19-42 per 100,000 person-years) and 24 non-lobar ICH (incidence rate 37, 95% CI 26-51 per 100,000 person-years). Age significantly increased the risk of lobar ICH (HR per 10 years increase 1.90; 95% CI 1.17-3.10) in the multivariable analysis, but not of non-lobar hemorrhage. Anticoagulant medication (HR 3.49; 95% CI 1.20-10.2) and male sex (HR 3.79; 95% CI 1.13-12.8) increased the risk of non-lobar but not lobar ICH.

CONCLUSION: This study shows an elevated risk of future ICH in patients with manifestations of, or risk factors for, cardiovascular, cerebrovascular or peripheral artery disease. Our data suggest that risk factors for ICH vary according to location, supporting the hypothesis of a differential pathophysiology of lobar and non-lobar ICH.

Original language	English
Article number	e0142338
Number of pages	10
Journal	PLoS ONE [E]
Volume	10
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0142338
Publication status	Published - 5 Nov 2015

Access to Document

10.1371/journal.pone.0142338

fetchObjectFinal published version, 202 KB

Cite this

Kremer, P. H. C., Jolink, W. M. T., Kappelle, L. J., Algra, A., Klijn, C. J. M., Van Der Graaf, Y., Grobbee, D. E., Rutten, G. E. H. M., Visseren, F. L. J., Moll, F. L., Kappelle, L. J., Mali, W. P. T. M., Doevendans, P. A., Halkes, P. H. A., Van Gijn, J., Kappelle, L. J., & Koudstaal, P. J. (2015). Risk factors for lobar and non-lobar intracerebral hemorrhage in patients with vascular disease. PLoS ONE [E], 10(11), Article e0142338. https://doi.org/10.1371/journal.pone.0142338

@article{9b0e46c2af3d4849980b9c034aceb88a,

title = "Risk factors for lobar and non-lobar intracerebral hemorrhage in patients with vascular disease",

abstract = "INTRODUCTION: Lobar and non-lobar non-traumatic intracerebral hemorrhage (ICH) are presumably caused by different types of small vessel diseases. The aim of this study was to assess risk factors for ICH according to location.METHODS: In two large prospective studies, SMART (n = 9088) and ESPRIT (n = 2625), including patients with manifest cardiovascular, cerebrovascular or peripheral artery disease or with vascular risk factors, we investigated potential risk factors for ICH during follow-up according to lobar or non-lobar location by Cox proportional hazards analyses.RESULTS: During 65,156 patient years of follow up 19 patients had lobar ICH (incidence rate 29, 95% CI 19-42 per 100,000 person-years) and 24 non-lobar ICH (incidence rate 37, 95% CI 26-51 per 100,000 person-years). Age significantly increased the risk of lobar ICH (HR per 10 years increase 1.90; 95% CI 1.17-3.10) in the multivariable analysis, but not of non-lobar hemorrhage. Anticoagulant medication (HR 3.49; 95% CI 1.20-10.2) and male sex (HR 3.79; 95% CI 1.13-12.8) increased the risk of non-lobar but not lobar ICH.CONCLUSION: This study shows an elevated risk of future ICH in patients with manifestations of, or risk factors for, cardiovascular, cerebrovascular or peripheral artery disease. Our data suggest that risk factors for ICH vary according to location, supporting the hypothesis of a differential pathophysiology of lobar and non-lobar ICH.",

author = "Kremer, {Philip H C} and Jolink, {Wilmar M T} and Kappelle, {L. Jaap} and Ale Algra and Klijn, {Catharina J M} and {Van Der Graaf}, Y. and Grobbee, {D. E.} and Rutten, {G. E H M} and Visseren, {F. L J} and Moll, {F. L.} and Kappelle, {L. J.} and Mali, {W. P T M} and Doevendans, {P. A.} and Halkes, {P. H A} and {Van Gijn}, J. and Kappelle, {L. J.} and Koudstaal, {P. J.}",

year = "2015",

month = nov,

day = "5",

doi = "10.1371/journal.pone.0142338",

language = "English",

volume = "10",

journal = "PLoS ONE [E]",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "11",

}

Kremer, PHC, Jolink, WMT, Kappelle, LJ , Algra, A, Klijn, CJM, Van Der Graaf, Y , Grobbee, DE , Rutten, GEHM , Visseren, FLJ, Moll, FL, Kappelle, LJ, Mali, WPTM, Doevendans, PA, Halkes, PHA, Van Gijn, J, Kappelle, LJ & Koudstaal, PJ 2015, 'Risk factors for lobar and non-lobar intracerebral hemorrhage in patients with vascular disease', PLoS ONE [E], vol. 10, no. 11, e0142338. https://doi.org/10.1371/journal.pone.0142338

TY - JOUR

T1 - Risk factors for lobar and non-lobar intracerebral hemorrhage in patients with vascular disease

AU - Kremer, Philip H C

AU - Jolink, Wilmar M T

AU - Kappelle, L. Jaap

AU - Algra, Ale

AU - Klijn, Catharina J M

AU - Van Der Graaf, Y.

AU - Grobbee, D. E.

AU - Rutten, G. E H M

AU - Visseren, F. L J

AU - Moll, F. L.

AU - Kappelle, L. J.

AU - Mali, W. P T M

AU - Doevendans, P. A.

AU - Halkes, P. H A

AU - Van Gijn, J.

AU - Kappelle, L. J.

AU - Koudstaal, P. J.

PY - 2015/11/5

Y1 - 2015/11/5

N2 - INTRODUCTION: Lobar and non-lobar non-traumatic intracerebral hemorrhage (ICH) are presumably caused by different types of small vessel diseases. The aim of this study was to assess risk factors for ICH according to location.METHODS: In two large prospective studies, SMART (n = 9088) and ESPRIT (n = 2625), including patients with manifest cardiovascular, cerebrovascular or peripheral artery disease or with vascular risk factors, we investigated potential risk factors for ICH during follow-up according to lobar or non-lobar location by Cox proportional hazards analyses.RESULTS: During 65,156 patient years of follow up 19 patients had lobar ICH (incidence rate 29, 95% CI 19-42 per 100,000 person-years) and 24 non-lobar ICH (incidence rate 37, 95% CI 26-51 per 100,000 person-years). Age significantly increased the risk of lobar ICH (HR per 10 years increase 1.90; 95% CI 1.17-3.10) in the multivariable analysis, but not of non-lobar hemorrhage. Anticoagulant medication (HR 3.49; 95% CI 1.20-10.2) and male sex (HR 3.79; 95% CI 1.13-12.8) increased the risk of non-lobar but not lobar ICH.CONCLUSION: This study shows an elevated risk of future ICH in patients with manifestations of, or risk factors for, cardiovascular, cerebrovascular or peripheral artery disease. Our data suggest that risk factors for ICH vary according to location, supporting the hypothesis of a differential pathophysiology of lobar and non-lobar ICH.

AB - INTRODUCTION: Lobar and non-lobar non-traumatic intracerebral hemorrhage (ICH) are presumably caused by different types of small vessel diseases. The aim of this study was to assess risk factors for ICH according to location.METHODS: In two large prospective studies, SMART (n = 9088) and ESPRIT (n = 2625), including patients with manifest cardiovascular, cerebrovascular or peripheral artery disease or with vascular risk factors, we investigated potential risk factors for ICH during follow-up according to lobar or non-lobar location by Cox proportional hazards analyses.RESULTS: During 65,156 patient years of follow up 19 patients had lobar ICH (incidence rate 29, 95% CI 19-42 per 100,000 person-years) and 24 non-lobar ICH (incidence rate 37, 95% CI 26-51 per 100,000 person-years). Age significantly increased the risk of lobar ICH (HR per 10 years increase 1.90; 95% CI 1.17-3.10) in the multivariable analysis, but not of non-lobar hemorrhage. Anticoagulant medication (HR 3.49; 95% CI 1.20-10.2) and male sex (HR 3.79; 95% CI 1.13-12.8) increased the risk of non-lobar but not lobar ICH.CONCLUSION: This study shows an elevated risk of future ICH in patients with manifestations of, or risk factors for, cardiovascular, cerebrovascular or peripheral artery disease. Our data suggest that risk factors for ICH vary according to location, supporting the hypothesis of a differential pathophysiology of lobar and non-lobar ICH.

UR - http://www.scopus.com/inward/record.url?scp=84951286729&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0142338

DO - 10.1371/journal.pone.0142338

M3 - Article

C2 - 26540190

AN - SCOPUS:84951286729

SN - 1932-6203

VL - 10

JO - PLoS ONE [E]

JF - PLoS ONE [E]

IS - 11

M1 - e0142338

ER -

Risk factors for lobar and non-lobar intracerebral hemorrhage in patients with vascular disease

Abstract

Access to Document

Other files and links

Fingerprint

Cite this