Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers

Heiman F.L. Wertheim; Margreet C. Vos; Alewijn Ott; Alex Van Belkum; Andreas Voss; Jan A.J.W. Kluytmans; Peter H.J. Van Keulen; Christina M.J.E. Vandenbroucke-Grauls; Marlene H.M. Meester; Henri A. Verbrugh

doi:10.1016/S0140-6736(04)16897-9

Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers

Heiman F.L. Wertheim^*, Margreet C. Vos, Alewijn Ott, Alex Van Belkum, Andreas Voss, Jan A.J.W. Kluytmans, Peter H.J. Van Keulen, Christina M.J.E. Vandenbroucke-Grauls, Marlene H.M. Meester, Henri A. Verbrugh

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

641 Citations (Scopus)

Abstract

Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14 008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1·2%) than in non-carriers (41/10 588, 0·4%; relative risk 3·0, 95% CI 2·0-4·7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0·005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0·006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous.

Original language	English
Pages (from-to)	703-705
Number of pages	3
Journal	Lancet
Volume	364
Issue number	9435
DOIs	https://doi.org/10.1016/S0140-6736(04)16897-9
Publication status	Published - 21 Aug 2004
Externally published	Yes

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Wertheim, H. F. L., Vos, M. C., Ott, A., Van Belkum, A., Voss, A., Kluytmans, J. A. J. W., Van Keulen, P. H. J., Vandenbroucke-Grauls, C. M. J. E., Meester, M. H. M., & Verbrugh, H. A. (2004). Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet, 364(9435), 703-705. https://doi.org/10.1016/S0140-6736(04)16897-9

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title = "Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers",

abstract = "Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14 008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1·2%) than in non-carriers (41/10 588, 0·4%; relative risk 3·0, 95% CI 2·0-4·7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0·005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0·006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous.",

author = "Wertheim, {Heiman F.L.} and Vos, {Margreet C.} and Alewijn Ott and {Van Belkum}, Alex and Andreas Voss and Kluytmans, {Jan A.J.W.} and {Van Keulen}, {Peter H.J.} and Vandenbroucke-Grauls, {Christina M.J.E.} and Meester, {Marlene H.M.} and Verbrugh, {Henri A.}",

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doi = "10.1016/S0140-6736(04)16897-9",

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T1 - Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers

AU - Wertheim, Heiman F.L.

AU - Vos, Margreet C.

AU - Ott, Alewijn

AU - Van Belkum, Alex

AU - Voss, Andreas

AU - Kluytmans, Jan A.J.W.

AU - Van Keulen, Peter H.J.

AU - Vandenbroucke-Grauls, Christina M.J.E.

AU - Meester, Marlene H.M.

AU - Verbrugh, Henri A.

PY - 2004/8/21

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N2 - Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14 008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1·2%) than in non-carriers (41/10 588, 0·4%; relative risk 3·0, 95% CI 2·0-4·7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0·005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0·006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous.

AB - Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14 008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1·2%) than in non-carriers (41/10 588, 0·4%; relative risk 3·0, 95% CI 2·0-4·7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0·005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0·006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous.

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Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers

Abstract

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