Rheumatoid factor production in the joint

F. C. Breedveld; H. G. Otten; M. R. Daha

doi:10.3109/03009749509100924

Rheumatoid factor production in the joint

F. C. Breedveld^*, H. G. Otten, M. R. Daha

^*Corresponding author for this work

Infection & Immunity

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Mononuclear cells derived from bone marrow, synovium and peripheral blood of patients with rheumatoid arthritis (RA) were examined for their capacity to produce rheumatoid factor (RF) in order to investigate the origin of circulating RF. The results demonstrate that mononuclear cells derived from bone mmow are able to produce IgG-, IgA- and IgM-RF and that the amounts of RF produced by bone manow cells are not significantly different from that by dissociated synovial cells. Since circulating immunoglobulins are mainly derived from the bone marrow this observation suggests that also RF circulating in RA patients mainly originates from the bone marrow.

Original language	English
Pages (from-to)	183-185
Number of pages	3
Journal	Scandinavian Journal of Rheumatology
Volume	24
Issue number	S101
DOIs	https://doi.org/10.3109/03009749509100924
Publication status	Published - 1 Jan 1995

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title = "Rheumatoid factor production in the joint",

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AU - Daha, M. R.

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Rheumatoid factor production in the joint

Abstract

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