TY - JOUR
T1 - Reward anticipation in individuals with subclinical psychotic experience
T2 - A functional MRI approach
AU - Michielse, Stijn
AU - Lange, Iris
AU - Bakker, Jindra
AU - Goossens, Liesbet
AU - Verhagen, Simone
AU - Papalini, Silvia
AU - Wichers, Marieke
AU - Lieverse, Ritsaert
AU - Schruers, Koen
AU - van Amelsvoort, Therese
AU - van Os, Jim
AU - Murray, Graham K.
AU - Marcelis, Machteld
N1 - Funding Information:
This study was funded by a research grant from the Weijerhorst Foundation, a NARSAD YI investigator grant (ID 21543) of the Brain and Behaviour Research Foundation to M. Marcelis and by a fellowship of the Dutch Brain Foundation to M. Wichers (Hersenstichting Nederland: 2012(1)−03).
Funding Information:
Jim van Os is or has been, in the last 3 years, an unrestricted research grant holder with, or has received financial compensation as an independent symposium speaker from: Lundbeck and Janssen. Machteld Marcelis has received, in the last 3 years, financial compensation as an independent symposium speaker from Janssen. All other authors report no biomedical financial interests or potential conflicts of interest.
Publisher Copyright:
© 2019
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019/12
Y1 - 2019/12
N2 - Previous research in patients with psychotic disorder has shown widespread abnormalities in brain activation during reward anticipation. Research at the level of subclinical psychotic experiences in individuals unexposed to antipsychotic medication is limited with inconclusive results. Therefore, brain activation during reward anticipation was examined in a larger sample of individuals with subclinical psychotic experiences (PE). Participants in the PE-group were included based on CAPE scores. A sample of emerging adults aged 16–26 years (n = =47) with PE and healthy controls (HC) (n = =40) underwent fMRI scanning. The Monetary Incentive Delay task was conducted with cues related to win, loss or neutral conditions. fMRI nonparametric tests were used to examine the reward versus neutral cue contrast. A significant main effect of the large win (€3.00) > neutral contrast was found in both groups showing activation in many brain areas, including classic reward regions. Whole brain analysis on the group comparison regarding the large win > neutral contrast showed significantly decreased activation in the right insula, putamen and supramarginal gyrus in the PE-group compared to controls. There was no group difference in the hypothesized reward-related region. Decreased activation in the right insula, putamen and supramarginal gyrus during reward anticipation in individuals with PE may be consistent with altered processing of sensory information, related to decreased emotional valuing and motivational tendencies and/or altered motor-cognitive processes. The absence of group differences in striatal activation suggests that activation here is intact in the earliest stages of psychosis and may exhibit progressive deterioration in as the disease develops.
AB - Previous research in patients with psychotic disorder has shown widespread abnormalities in brain activation during reward anticipation. Research at the level of subclinical psychotic experiences in individuals unexposed to antipsychotic medication is limited with inconclusive results. Therefore, brain activation during reward anticipation was examined in a larger sample of individuals with subclinical psychotic experiences (PE). Participants in the PE-group were included based on CAPE scores. A sample of emerging adults aged 16–26 years (n = =47) with PE and healthy controls (HC) (n = =40) underwent fMRI scanning. The Monetary Incentive Delay task was conducted with cues related to win, loss or neutral conditions. fMRI nonparametric tests were used to examine the reward versus neutral cue contrast. A significant main effect of the large win (€3.00) > neutral contrast was found in both groups showing activation in many brain areas, including classic reward regions. Whole brain analysis on the group comparison regarding the large win > neutral contrast showed significantly decreased activation in the right insula, putamen and supramarginal gyrus in the PE-group compared to controls. There was no group difference in the hypothesized reward-related region. Decreased activation in the right insula, putamen and supramarginal gyrus during reward anticipation in individuals with PE may be consistent with altered processing of sensory information, related to decreased emotional valuing and motivational tendencies and/or altered motor-cognitive processes. The absence of group differences in striatal activation suggests that activation here is intact in the earliest stages of psychosis and may exhibit progressive deterioration in as the disease develops.
KW - Emerging adults
KW - fMRI
KW - Mild psychopathology
KW - Monetary reward
KW - Reward anticipation
KW - Subclinical psychotic experiences
UR - http://www.scopus.com/inward/record.url?scp=85074493680&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2019.10.002
DO - 10.1016/j.euroneuro.2019.10.002
M3 - Article
C2 - 31685359
AN - SCOPUS:85074493680
SN - 0924-977X
VL - 29
SP - 1374
EP - 1385
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 12
ER -