TY - JOUR
T1 - Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects
AU - Numan, Tianne
AU - van Dellen, Edwin
AU - Vleggaar, Frank P
AU - van Vlieberghe, Paul
AU - Stam, Cornelis J
AU - Slooter, Arjen J C
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Support was provided solely from institutional and/or departmental sources.
Publisher Copyright:
© EEG and Clinical Neuroscience Society (ECNS) 2019.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - BACKGROUND: Despite widespread application, little is known about the neurophysiological effects of light sedation with midazolam or propofol, particularly in older subjects. The aim of this study was to assess the effects of light sedation with midazolam or propofol on a variety of EEG measures in older subjects.METHODS: In patients (≥60 years without neuropsychiatric disease such as delirium), 2 EEG recordings were performed, before and after administration of either midazolam (n = 22) or propofol (n = 26) to facilitate an endoscopic procedure. Power spectrum, functional connectivity, and network topology based on the minimum spanning tree (MST) were compared within subjects.RESULTS: Midazolam and propofol administration resulted in Richmond Agitation and Sedation Scale levels between 0 and -4 and between -2 and -4, respectively. Both agents altered the power spectra with increased delta (0.5-4 Hz) and decreased alpha (8-13 Hz) power. Only propofol was found to significantly reduce functional connectivity. In the beta frequency band, the MST was more integrated during midazolam sedation. Propofol sedation resulted in a less integrated network in the alpha frequency band.CONCLUSION: Despite the different levels of light sedation with midazolam and propofol, similar changes in power were found. Functional connectivity and network topology showed differences between midazolam and propofol sedation. Future research should establish if these differences are caused by the different levels of sedation or the mechanism of action of these agents.
AB - BACKGROUND: Despite widespread application, little is known about the neurophysiological effects of light sedation with midazolam or propofol, particularly in older subjects. The aim of this study was to assess the effects of light sedation with midazolam or propofol on a variety of EEG measures in older subjects.METHODS: In patients (≥60 years without neuropsychiatric disease such as delirium), 2 EEG recordings were performed, before and after administration of either midazolam (n = 22) or propofol (n = 26) to facilitate an endoscopic procedure. Power spectrum, functional connectivity, and network topology based on the minimum spanning tree (MST) were compared within subjects.RESULTS: Midazolam and propofol administration resulted in Richmond Agitation and Sedation Scale levels between 0 and -4 and between -2 and -4, respectively. Both agents altered the power spectra with increased delta (0.5-4 Hz) and decreased alpha (8-13 Hz) power. Only propofol was found to significantly reduce functional connectivity. In the beta frequency band, the MST was more integrated during midazolam sedation. Propofol sedation resulted in a less integrated network in the alpha frequency band.CONCLUSION: Despite the different levels of light sedation with midazolam and propofol, similar changes in power were found. Functional connectivity and network topology showed differences between midazolam and propofol sedation. Future research should establish if these differences are caused by the different levels of sedation or the mechanism of action of these agents.
KW - electroencephalography
KW - functional connectivity
KW - midazolam
KW - minimum spanning tree (MST)
KW - propofol
UR - http://www.scopus.com/inward/record.url?scp=85066845923&partnerID=8YFLogxK
U2 - 10.1177/1550059419838938
DO - 10.1177/1550059419838938
M3 - Article
C2 - 31106583
SN - 1550-0594
VL - 50
SP - 436
EP - 443
JO - Clinical EEG and neuroscience
JF - Clinical EEG and neuroscience
IS - 6
ER -