Respiratory syncytial virus infection and novel interventions

Annefleur C. Langedijk, Louis J. Bont*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The large global burden of respiratory syncytial virus (RSV) respiratory tract infections in young children and older adults has gained increased recognition in recent years. Recent discoveries regarding the neutralization-specific viral epitopes of the pre-fusion RSV glycoprotein have led to a shift from empirical to structure-based design of RSV therapeutics, and controlled human infection model studies have provided early-stage proof of concept for novel RSV monoclonal antibodies, vaccines and antiviral drugs. The world’s first vaccines and first monoclonal antibody to prevent RSV among older adults and all infants, respectively, have recently been approved. Large-scale introduction of RSV prophylactics emphasizes the need for active surveillance to understand the global impact of these interventions over time and to timely identify viral mutants that are able to escape novel prophylactics. In this Review, we provide an overview of RSV interventions in clinical development, highlighting global disease burden, seasonality, pathogenesis, and host and viral factors related to RSV immunity.

Original languageEnglish
Pages (from-to)734-749
Number of pages16
JournalNature Reviews Microbiology
Issue number11
Early online date12 Jul 2023
Publication statusPublished - Nov 2023


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