TY - JOUR
T1 - Respiratory Pathogen Detection in Children
T2 - Saliva as a Diagnostic Specimen
AU - De Koff, Emma M.
AU - Euser, Sjoerd M.
AU - Badoux, Paul
AU - Sluiter-Post, Judith
AU - Eggink, Dirk
AU - Sanders, Elisabeth A.M.
AU - Van Houten, Marlies A.
N1 - Funding Information:
M.A.v.H. has received grants from Pfizer unrelated to this work. The other authors have no conflicts of interest to disclose.
Funding Information:
This work was funded by the Spaarne Gasthuis Hoofddorp and Haarlem and the Regional Public Health Laboratory Kennemerland Haarlem. No external funding was received.
Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/9
Y1 - 2021/9
N2 - We compared pathogen detection between saliva, nasopharyngeal and oropharyngeal swabs in children with respiratory symptoms. The sensitivity in nasopharyngeal swabs was 93% (95% confidence interval [CI]: 78%-98%), in oropharyngeal swabs 79% (95% CI: 60%-90%), in saliva overall 76% (95% CI: 58%-88%) and in 18 saliva samples collected with drooling or sponges, 94% (95% CI: 74%-99%). Saliva could be a relevant specimen alternative.
AB - We compared pathogen detection between saliva, nasopharyngeal and oropharyngeal swabs in children with respiratory symptoms. The sensitivity in nasopharyngeal swabs was 93% (95% confidence interval [CI]: 78%-98%), in oropharyngeal swabs 79% (95% CI: 60%-90%), in saliva overall 76% (95% CI: 58%-88%) and in 18 saliva samples collected with drooling or sponges, 94% (95% CI: 74%-99%). Saliva could be a relevant specimen alternative.
KW - diagnostics
KW - pediatrics
KW - respiratory pathogens
KW - saliva
UR - http://www.scopus.com/inward/record.url?scp=85112773443&partnerID=8YFLogxK
U2 - 10.1097/INF.0000000000003191
DO - 10.1097/INF.0000000000003191
M3 - Article
C2 - 34260500
AN - SCOPUS:85112773443
SN - 0891-3668
VL - 40
SP - E351-E353
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 9
ER -