Resolving the cadherin-F-actin connection

Mitchell K L Han; Johan de Rooij

doi:10.1038/ncb3457

Resolving the cadherin-F-actin connection

Mitchell K L Han
, Johan de Rooij^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.

Original language	English
Pages (from-to)	14-16
Number of pages	3
Journal	Nature Cell Biology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1038/ncb3457
Publication status	Published - Jan 2017

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ncb3457Final published version, 328 KBLicence: Taverne

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AB - Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.

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Resolving the cadherin-F-actin connection

Abstract

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