Resident adult neural stem cells in Parkinson's disease - The brain's own repair system?

Simone A. Van Den Berge, Miriam E. Van Strien, Elly M. Hol*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

One important pathological process in the brain of Parkinson disease (PD) patients is the degeneration of the dopaminergic neurons in the substantia nigra, which leads to a decline in striatal dopamine levels and motor dysfunction. A major clinical problem is that this degenerative process currently cannot be stopped or reversed. Expectations from the restorative capacity of neural stem cells (NSCs) are high, as these cells can potentially replace the degenerating neurons. The discovery of the presence of NSCs in the adult human brain has instigated research into the potential of these cells as a resource to promote brain repair in neurodegenerative diseases. Neural stem and progenitor cells reside in the subventricular zone (SVZ), which is closely situated to the striatum, which is affected in PD. Therefore, restoring the dopamine levels in the striatum of PD patients through stimulating endogenous NSCs in the nearby SVZ to migrate into the striatum and differentiate into dopaminergic neurons might thus be an attractive future therapeutic approach. We will review the reported changes in NSCs in the SVZ of PD animal models and PD patients, which are due to a lack of striatal dopamine. Furthermore, we will summarise the reports that describe efforts to stimulate NSCs to replace dopaminergic cells in the SN and restore striatal dopamine levels. In our opinion, mobilizing the endogenous SVZ NSCs to replenish striatal dopamine is an attractive approach to alleviate the motor symptoms in PD patients, without the ethical and immunological challenges of transplantation of NSCs and foetal brain tissue. © 2013 Elsevier B.V.

Original languageEnglish
Pages (from-to)117-127
Number of pages11
JournalEuropean Journal of Pharmacology
Volume719
Issue number1-3
DOIs
Publication statusPublished - 6 Aug 2013

Keywords

  • Dopaminergic neurons
  • Neural stem cells
  • Parkinson's disease
  • Subventricular zone
  • Neurogenesis
  • SUBVENTRICULAR ZONE NEUROGENESIS
  • MAMMALIAN SUBSTANTIA-NIGRA
  • D-3 RECEPTOR STIMULATION
  • ROSTRAL MIGRATORY STREAM
  • GROWTH-FACTOR-ALPHA
  • DOPAMINERGIC-NEURONS
  • OLFACTORY-BULB
  • NEUROTROPHIC FACTOR
  • PROGENITOR CELLS
  • MOUSE MODEL

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