Report on the Clinical Outcomes of Permanent Breast Seed Implant for Early-Stage Breast Cancers

Jean-Philippe Pignol*, Jean-Michel Caudrelier, Juanita Crook, Claire McCann, Pauline Truong, Helena A. Verkooijen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: Permanent breast seed implant is an accelerated partial breast irradiation technique realizing the insertion of 103 Pd seeds in the seroma after lumpectomy. We report the 5-year efficacy and tolerance for a cohort, pooling patients from 3 clinical trials.

Methods and Materials: The trials accrued postmenopausal patients with infiltrating ductal carcinoma or ductal carcinoma in situ

Results: The cohort included 134 patients, and the observed local recurrence rate at a median follow-up period of 63 months was 1.2% +/- 1.2%, similar to the estimate for whole breast irradiation (P=.23), significantly better than for surgery alone (relative risk 0.27; P

Conclusions: The 5-year data suggest that permanent breast seed implantation is a safe accelerated partial breast irradiation option after lumpectomy for early-stage breast cancer with a tolerance profile similar to that of whole breast irradiation. (C) 2015 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)614-621
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume93
Issue number3
DOIs
Publication statusPublished - 1 Nov 2015

Keywords

  • RADIATION-THERAPY
  • RANDOMIZED-TRIAL
  • INTRAOPERATIVE RADIOTHERAPY
  • CONSENSUS STATEMENT
  • CONSERVING THERAPY
  • LOCAL-CONTROL
  • IRRADIATION
  • BRACHYTHERAPY
  • RECURRENCE
  • CARCINOMA

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