Abstract
Purpose: Permanent breast seed implant is an accelerated partial breast irradiation technique realizing the insertion of 103 Pd seeds in the seroma after lumpectomy. We report the 5-year efficacy and tolerance for a cohort, pooling patients from 3 clinical trials.
Methods and Materials: The trials accrued postmenopausal patients with infiltrating ductal carcinoma or ductal carcinoma in situ
Results: The cohort included 134 patients, and the observed local recurrence rate at a median follow-up period of 63 months was 1.2% +/- 1.2%, similar to the estimate for whole breast irradiation (P=.23), significantly better than for surgery alone (relative risk 0.27; P
Conclusions: The 5-year data suggest that permanent breast seed implantation is a safe accelerated partial breast irradiation option after lumpectomy for early-stage breast cancer with a tolerance profile similar to that of whole breast irradiation. (C) 2015 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 614-621 |
Number of pages | 8 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 93 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Nov 2015 |
Keywords
- RADIATION-THERAPY
- RANDOMIZED-TRIAL
- INTRAOPERATIVE RADIOTHERAPY
- CONSENSUS STATEMENT
- CONSERVING THERAPY
- LOCAL-CONTROL
- IRRADIATION
- BRACHYTHERAPY
- RECURRENCE
- CARCINOMA