Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter

Sila Genc; Maxime Chamberland; Kristin Koller; Chantal M.W. Tax; Hui Zhang; Marco Palombo; Derek K. Jones

doi:10.1007/978-3-030-73018-5_11

Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter

Sila Genc^*, Maxime Chamberland, Kristin Koller, Chantal M.W. Tax, Hui Zhang, Marco Palombo, Derek K. Jones

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Diffusion magnetic resonance imaging is a technique which has long been used to study white matter microstructure in vivo. Recent advancements in hardware and modelling techniques have opened up interest in disentangling tissue compartments in the grey matter. In this study, we evaluate the repeatability of soma and neurite density imaging in a sample of six healthy adults scanned five times on an ultra-strong gradient magnetic resonance scanner (300 mT/m). Repeatability was expressed as an intraclass correlation coefficient (ICC). Our findings reveal that measures of soma density (mean ICC = 0.976), neurite density (mean ICC = 0.959) and apparent soma size (mean ICC = 0.923) are highly reliable across multiple cortical and subcortical networks. Overall, we demonstrate the promise of moving advanced grey matter microstructural imaging towards applications of development, ageing, and disease.

Original language	English
Title of host publication	Computational Diffusion MRI - International MICCAI Workshop
Editors	Noemi Gyori, Jana Hutter, Vishwesh Nath, Marco Palombo, Marco Pizzolato, Fan Zhang
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	135-145
Number of pages	11
ISBN (Print)	9783030730178
DOIs	https://doi.org/10.1007/978-3-030-73018-5_11
Publication status	Published - 2021
Externally published	Yes
Event	International Workshop on Computational Diffusion MRI, CDMRI 2020 held in conjunction with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2020 - Virtual, Online Duration: 8 Oct 2020 → 8 Oct 2020

Publication series

Name	Mathematics and Visualization
ISSN (Print)	1612-3786
ISSN (Electronic)	2197-666X

Conference

Conference	International Workshop on Computational Diffusion MRI, CDMRI 2020 held in conjunction with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2020
City	Virtual, Online
Period	8/10/20 → 8/10/20

Keywords

Grey matter
Microstructure
Neurite density
Repeatability
SANDI
Soma density
Soma radius

Access to Document

10.1007/978-3-030-73018-5_11

Cite this

Genc, S., Chamberland, M., Koller, K., Tax, C. M. W., Zhang, H., Palombo, M., & Jones, D. K. (2021). Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter. In N. Gyori, J. Hutter, V. Nath, M. Palombo, M. Pizzolato, & F. Zhang (Eds.), Computational Diffusion MRI - International MICCAI Workshop (pp. 135-145). (Mathematics and Visualization). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-73018-5_11

Genc, Sila ; Chamberland, Maxime ; Koller, Kristin et al. / Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter. Computational Diffusion MRI - International MICCAI Workshop. editor / Noemi Gyori ; Jana Hutter ; Vishwesh Nath ; Marco Palombo ; Marco Pizzolato ; Fan Zhang. Springer Science and Business Media Deutschland GmbH, 2021. pp. 135-145 (Mathematics and Visualization).

@inproceedings{0f8c6e4b01f04c56b981d64489821550,

title = "Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter",

abstract = "Diffusion magnetic resonance imaging is a technique which has long been used to study white matter microstructure in vivo. Recent advancements in hardware and modelling techniques have opened up interest in disentangling tissue compartments in the grey matter. In this study, we evaluate the repeatability of soma and neurite density imaging in a sample of six healthy adults scanned five times on an ultra-strong gradient magnetic resonance scanner (300 mT/m). Repeatability was expressed as an intraclass correlation coefficient (ICC). Our findings reveal that measures of soma density (mean ICC = 0.976), neurite density (mean ICC = 0.959) and apparent soma size (mean ICC = 0.923) are highly reliable across multiple cortical and subcortical networks. Overall, we demonstrate the promise of moving advanced grey matter microstructural imaging towards applications of development, ageing, and disease.",

keywords = "Grey matter, Microstructure, Neurite density, Repeatability, SANDI, Soma density, Soma radius",

author = "Sila Genc and Maxime Chamberland and Kristin Koller and Tax, \{Chantal M.W.\} and Hui Zhang and Marco Palombo and Jones, \{Derek K.\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.; International Workshop on Computational Diffusion MRI, CDMRI 2020 held in conjunction with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2020 ; Conference date: 08-10-2020 Through 08-10-2020",

year = "2021",

doi = "10.1007/978-3-030-73018-5\_11",

language = "English",

isbn = "9783030730178",

series = "Mathematics and Visualization",

publisher = "Springer Science and Business Media Deutschland GmbH",

pages = "135--145",

editor = "Noemi Gyori and Jana Hutter and Vishwesh Nath and Marco Palombo and Marco Pizzolato and Fan Zhang",

booktitle = "Computational Diffusion MRI - International MICCAI Workshop",

address = "Germany",

}

Genc, S, Chamberland, M, Koller, K, Tax, CMW, Zhang, H, Palombo, M & Jones, DK 2021, Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter. in N Gyori, J Hutter, V Nath, M Palombo, M Pizzolato & F Zhang (eds), Computational Diffusion MRI - International MICCAI Workshop. Mathematics and Visualization, Springer Science and Business Media Deutschland GmbH, pp. 135-145, International Workshop on Computational Diffusion MRI, CDMRI 2020 held in conjunction with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2020, Virtual, Online, 8/10/20. https://doi.org/10.1007/978-3-030-73018-5_11

Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter. / Genc, Sila; Chamberland, Maxime; Koller, Kristin et al.
Computational Diffusion MRI - International MICCAI Workshop. ed. / Noemi Gyori; Jana Hutter; Vishwesh Nath; Marco Palombo; Marco Pizzolato; Fan Zhang. Springer Science and Business Media Deutschland GmbH, 2021. p. 135-145 (Mathematics and Visualization).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter

AU - Genc, Sila

AU - Chamberland, Maxime

AU - Koller, Kristin

AU - Tax, Chantal M.W.

AU - Zhang, Hui

AU - Palombo, Marco

AU - Jones, Derek K.

PY - 2021

Y1 - 2021

N2 - Diffusion magnetic resonance imaging is a technique which has long been used to study white matter microstructure in vivo. Recent advancements in hardware and modelling techniques have opened up interest in disentangling tissue compartments in the grey matter. In this study, we evaluate the repeatability of soma and neurite density imaging in a sample of six healthy adults scanned five times on an ultra-strong gradient magnetic resonance scanner (300 mT/m). Repeatability was expressed as an intraclass correlation coefficient (ICC). Our findings reveal that measures of soma density (mean ICC = 0.976), neurite density (mean ICC = 0.959) and apparent soma size (mean ICC = 0.923) are highly reliable across multiple cortical and subcortical networks. Overall, we demonstrate the promise of moving advanced grey matter microstructural imaging towards applications of development, ageing, and disease.

AB - Diffusion magnetic resonance imaging is a technique which has long been used to study white matter microstructure in vivo. Recent advancements in hardware and modelling techniques have opened up interest in disentangling tissue compartments in the grey matter. In this study, we evaluate the repeatability of soma and neurite density imaging in a sample of six healthy adults scanned five times on an ultra-strong gradient magnetic resonance scanner (300 mT/m). Repeatability was expressed as an intraclass correlation coefficient (ICC). Our findings reveal that measures of soma density (mean ICC = 0.976), neurite density (mean ICC = 0.959) and apparent soma size (mean ICC = 0.923) are highly reliable across multiple cortical and subcortical networks. Overall, we demonstrate the promise of moving advanced grey matter microstructural imaging towards applications of development, ageing, and disease.

KW - Grey matter

KW - Microstructure

KW - Neurite density

KW - Repeatability

KW - SANDI

KW - Soma density

KW - Soma radius

UR - https://www.scopus.com/pages/publications/85116897970

U2 - 10.1007/978-3-030-73018-5_11

DO - 10.1007/978-3-030-73018-5_11

M3 - Conference contribution

AN - SCOPUS:85116897970

SN - 9783030730178

T3 - Mathematics and Visualization

SP - 135

EP - 145

BT - Computational Diffusion MRI - International MICCAI Workshop

A2 - Gyori, Noemi

A2 - Hutter, Jana

A2 - Nath, Vishwesh

A2 - Palombo, Marco

A2 - Pizzolato, Marco

A2 - Zhang, Fan

PB - Springer Science and Business Media Deutschland GmbH

T2 - International Workshop on Computational Diffusion MRI, CDMRI 2020 held in conjunction with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2020

Y2 - 8 October 2020 through 8 October 2020

ER -

Genc S, Chamberland M, Koller K, Tax CMW, Zhang H, Palombo M et al. Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter. In Gyori N, Hutter J, Nath V, Palombo M, Pizzolato M, Zhang F, editors, Computational Diffusion MRI - International MICCAI Workshop. Springer Science and Business Media Deutschland GmbH. 2021. p. 135-145. (Mathematics and Visualization). doi: 10.1007/978-3-030-73018-5_11

Repeatability of Soma and Neurite Metrics in Cortical and Subcortical Grey Matter

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Keywords

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