TY - JOUR
T1 - Renal sinus fat and renal hemodynamics
T2 - a cross-sectional analysis
AU - Spit, Karlinde A
AU - Muskiet, Marcel H A
AU - Tonneijck, Lennart
AU - Smits, Mark M
AU - Kramer, Mark H H
AU - Joles, Jaap A
AU - de Boer, Anneloes
AU - van Raalte, Daniel H
N1 - Funding Information:
The research leading to these results received funding from the European Union under Grant agreement 282521, the SAFEGUARD project) and the Dutch Kidney Foundation (under Grant agreement IP12.87). The funders had no role in the study design; collection, analysis, and interpretation of data; writing of the manuscript; or decision to submit the manuscript for publication.
Funding Information:
The authors thank J. Boerop and S. Gassman (Diabetes Center, Department of Internal Medicine, VU University Medical Center) for their excellent practical support during the test visits.
Publisher Copyright:
© 2019, The Author(s).
PY - 2020/2
Y1 - 2020/2
N2 - OBJECTIVES: Increased renal sinus fat (RSF) is associated with hypertension and chronic kidney disease, but underlying mechanisms are incompletely understood. We evaluated relations between RSF and gold-standard measures of renal hemodynamics in type 2 diabetes (T2D) patients.METHODS: Fifty-one T2D patients [age 63 ± 7 years; BMI 31 (28-34) kg/m2; GFR 83 ± 16 mL/min/1.73 m2] underwent MRI-scanning to quantify RSF volume, and subcutaneous and visceral adipose tissue compartments (SAT and VAT, respectively). GFR and effective renal plasma flow (ERPF) were determined by inulin and PAH clearances, respectively. Effective renal vascular resistance (ERVR) was calculated.RESULTS: RSF correlated negatively with GFR (r = - 0.38; p = 0.006) and ERPF (r = - 0.38; p = 0.006) and positively with mean arterial pressure (MAP) (r = 0.29; p = 0.039) and ERVR (r = 0.45, p = 0.001), which persisted after adjustment for VAT, MAP, sex, and BMI. After correction for age, ERVR remained significantly related to RSF.CONCLUSIONS: In T2D patients, higher RSF volume was negatively associated to GFR. In addition, RSF volume was positively associated with increased renal vascular resistance, which may mediate hypertension and CKD development. Further research is needed to investigate how RSF may alter the (afferent) vascular resistance of the renal vasculature.
AB - OBJECTIVES: Increased renal sinus fat (RSF) is associated with hypertension and chronic kidney disease, but underlying mechanisms are incompletely understood. We evaluated relations between RSF and gold-standard measures of renal hemodynamics in type 2 diabetes (T2D) patients.METHODS: Fifty-one T2D patients [age 63 ± 7 years; BMI 31 (28-34) kg/m2; GFR 83 ± 16 mL/min/1.73 m2] underwent MRI-scanning to quantify RSF volume, and subcutaneous and visceral adipose tissue compartments (SAT and VAT, respectively). GFR and effective renal plasma flow (ERPF) were determined by inulin and PAH clearances, respectively. Effective renal vascular resistance (ERVR) was calculated.RESULTS: RSF correlated negatively with GFR (r = - 0.38; p = 0.006) and ERPF (r = - 0.38; p = 0.006) and positively with mean arterial pressure (MAP) (r = 0.29; p = 0.039) and ERVR (r = 0.45, p = 0.001), which persisted after adjustment for VAT, MAP, sex, and BMI. After correction for age, ERVR remained significantly related to RSF.CONCLUSIONS: In T2D patients, higher RSF volume was negatively associated to GFR. In addition, RSF volume was positively associated with increased renal vascular resistance, which may mediate hypertension and CKD development. Further research is needed to investigate how RSF may alter the (afferent) vascular resistance of the renal vasculature.
KW - Diabetic kidney disease
KW - Hypertension
KW - Renal hemodynamics
KW - Renal sinus fat
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85071424212&partnerID=8YFLogxK
U2 - 10.1007/s10334-019-00773-z
DO - 10.1007/s10334-019-00773-z
M3 - Article
C2 - 31471702
SN - 0968-5243
VL - 33
SP - 73
EP - 80
JO - Magma - Magnetic Resonance Materials In Physics Biology And Medicine
JF - Magma - Magnetic Resonance Materials In Physics Biology And Medicine
IS - 1
ER -