Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Denielli da Silva Gonçalves Bos; Chris Happé; Ingrid Schalij; Wioletta Pijacka; Julian F R Paton; Christophe Guignabert; Ly Tu; Raphaël Thuillet; Harm-Jan Bogaard; Albert C van Rossum; Anton Vonk-Noordegraaf; Frances S de Man; M Louis Handoko

doi:10.1016/j.jacbts.2016.09.007

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Denielli da Silva Gonçalves Bos, Chris Happé, Ingrid Schalij, Wioletta Pijacka, Julian F R Paton, Christophe Guignabert, Ly Tu, Raphaël Thuillet, Harm-Jan Bogaard, Albert C van Rossum, Anton Vonk-Noordegraaf, Frances S de Man, M Louis Handoko

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

Original language	English
Pages (from-to)	22-35
Number of pages	14
Journal	JACC: Basic to Translational Science
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.jacbts.2016.09.007
Publication status	Published - Feb 2017
Externally published	Yes

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da Silva Gonçalves Bos, D., Happé, C., Schalij, I., Pijacka, W., Paton, J. F. R., Guignabert, C., Tu, L., Thuillet, R., Bogaard, H.-J., van Rossum, A. C., Vonk-Noordegraaf, A., de Man, F. S., & Handoko, M. L. (2017). Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension. JACC: Basic to Translational Science, 2(1), 22-35. https://doi.org/10.1016/j.jacbts.2016.09.007

@article{0dd37886663b42b6b04fc898addc1b0a,

title = "Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension",

abstract = "Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.",

author = "{da Silva Gon{\c c}alves Bos}, Denielli and Chris Happ{\'e} and Ingrid Schalij and Wioletta Pijacka and Paton, {Julian F R} and Christophe Guignabert and Ly Tu and Rapha{\"e}l Thuillet and Harm-Jan Bogaard and {van Rossum}, {Albert C} and Anton Vonk-Noordegraaf and {de Man}, {Frances S} and Handoko, {M Louis}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = feb,

doi = "10.1016/j.jacbts.2016.09.007",

language = "English",

volume = "2",

pages = "22--35",

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da Silva Gonçalves Bos, D, Happé, C, Schalij, I, Pijacka, W, Paton, JFR, Guignabert, C, Tu, L, Thuillet, R, Bogaard, H-J, van Rossum, AC, Vonk-Noordegraaf, A, de Man, FS & Handoko, ML 2017, 'Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension', JACC: Basic to Translational Science, vol. 2, no. 1, pp. 22-35. https://doi.org/10.1016/j.jacbts.2016.09.007

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension. / da Silva Gonçalves Bos, Denielli; Happé, Chris; Schalij, Ingrid et al.
In: JACC: Basic to Translational Science, Vol. 2, No. 1, 02.2017, p. 22-35.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

AU - da Silva Gonçalves Bos, Denielli

AU - Happé, Chris

AU - Schalij, Ingrid

AU - Pijacka, Wioletta

AU - Paton, Julian F R

AU - Guignabert, Christophe

AU - Tu, Ly

AU - Thuillet, Raphaël

AU - Bogaard, Harm-Jan

AU - van Rossum, Albert C

AU - Vonk-Noordegraaf, Anton

AU - de Man, Frances S

AU - Handoko, M Louis

PY - 2017/2

Y1 - 2017/2

N2 - Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

AB - Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

U2 - 10.1016/j.jacbts.2016.09.007

DO - 10.1016/j.jacbts.2016.09.007

M3 - Article

C2 - 29034356

SN - 2452-302X

VL - 2

SP - 22

EP - 35

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 1

ER -

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

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