Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography

Margreet F Sanders; Pieter Jan van Doormaal; Martine M A Beeftink; Michiel L Bots; Fadl Elmula M Fadl Elmula; Jesse Habets; Frank Hammer; Pavel Hoffmann; Lotte Jacobs; Patrick B Mark; Alexandre Persu; Jean Renkin; Giles Roditi; Wilko Spiering; Jan A Staessen; Alison H Taylor; Willemien L Verloop; Eva E Vink; Evert-Jan Vonken; Michiel Voskuil; Tim Leiner; Peter J Blankestijn

doi:10.1007/s00330-017-4770-7

Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography

Margreet F Sanders, Pieter Jan van Doormaal, Martine M A Beeftink, Michiel L Bots, Fadl Elmula M Fadl Elmula, Jesse Habets, Frank Hammer, Pavel Hoffmann, Lotte Jacobs, Patrick B Mark, Alexandre Persu, Jean Renkin, Giles Roditi, Wilko Spiering, Jan A Staessen, Alison H Taylor, Willemien L Verloop, Eva E Vink, Evert-Jan Vonken, Michiel VoskuilTim Leiner, Peter J Blankestijn,

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Relatively little is known about the incidence of long-term renal damage after renal denervation (RDN), a potential new treatment for hypertension. In this study the incidence of renal artery and parenchymal changes, assessed with contrast-enhanced magnetic resonance angiography (MRA) after RDN, is investigated.

METHODS: This study is an initiative of ENCOReD, a collaboration of hypertension expert centres. Patients in whom an MRA was performed before and after RDN were included. Scans were evaluated by two independent, blinded radiologists. Primary outcome was the change in renal artery morphology and parenchyma.

RESULTS: MRAs from 96 patients were analysed. Before RDN, 41 renal anomalies were observed, of which 29 mostly mild renal artery stenoses. After a median time of 366 days post RDN, MRA showed a new stenosis (25-49% lumen reduction) in two patients and progression of pre-existing lumen reduction in a single patient. No other renal changes were observed and renal function remained stable.

CONCLUSIONS: We observed new or progressed renal artery stenosis in three out of 96 patients, after a median time of 12 months post RDN (3.1%). Procedural angiographies showed that ablations were applied near the observed stenosis in only one of the three patients.

KEY POINTS: • The incidence of vascular changes 12 months post RDN was 3.1%. • No renal vascular or parenchymal changes other than stenoses were observed. • Ablations were applied near the stenosis in only one of three patients.

Original language	English
Pages (from-to)	3934–3941
Number of pages	8
Journal	European Radiology
Volume	27
Issue number	9
Early online date	2017
DOIs	https://doi.org/10.1007/s00330-017-4770-7
Publication status	Published - Sept 2017

Access to Document

10.1007/s00330-017-4770-7

sandersFinal published version, 486 KB

Cite this

Sanders, M. F., van Doormaal, P. J., Beeftink, M. M. A., Bots, M. L., Fadl Elmula, F. E. M., Habets, J., Hammer, F., Hoffmann, P., Jacobs, L., Mark, P. B., Persu, A., Renkin, J., Roditi, G., Spiering, W., Staessen, J. A., Taylor, A. H., Verloop, W. L., Vink, E. E., Vonken, E.-J. (2017). Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography. European Radiology, 27(9), 3934–3941. https://doi.org/10.1007/s00330-017-4770-7

@article{85011625452c4dfbb52b76cc2523ff5a,

title = "Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography",

abstract = "OBJECTIVES: Relatively little is known about the incidence of long-term renal damage after renal denervation (RDN), a potential new treatment for hypertension. In this study the incidence of renal artery and parenchymal changes, assessed with contrast-enhanced magnetic resonance angiography (MRA) after RDN, is investigated.METHODS: This study is an initiative of ENCOReD, a collaboration of hypertension expert centres. Patients in whom an MRA was performed before and after RDN were included. Scans were evaluated by two independent, blinded radiologists. Primary outcome was the change in renal artery morphology and parenchyma.RESULTS: MRAs from 96 patients were analysed. Before RDN, 41 renal anomalies were observed, of which 29 mostly mild renal artery stenoses. After a median time of 366 days post RDN, MRA showed a new stenosis (25-49% lumen reduction) in two patients and progression of pre-existing lumen reduction in a single patient. No other renal changes were observed and renal function remained stable.CONCLUSIONS: We observed new or progressed renal artery stenosis in three out of 96 patients, after a median time of 12 months post RDN (3.1%). Procedural angiographies showed that ablations were applied near the observed stenosis in only one of the three patients.KEY POINTS: • The incidence of vascular changes 12 months post RDN was 3.1%. • No renal vascular or parenchymal changes other than stenoses were observed. • Ablations were applied near the stenosis in only one of three patients.",

author = "Sanders, {Margreet F} and {van Doormaal}, {Pieter Jan} and Beeftink, {Martine M A} and Bots, {Michiel L} and {Fadl Elmula}, {Fadl Elmula M} and Jesse Habets and Frank Hammer and Pavel Hoffmann and Lotte Jacobs and Mark, {Patrick B} and Alexandre Persu and Jean Renkin and Giles Roditi and Wilko Spiering and Staessen, {Jan A} and Taylor, {Alison H} and Verloop, {Willemien L} and Vink, {Eva E} and Evert-Jan Vonken and Michiel Voskuil and Tim Leiner and Blankestijn, {Peter J}",

note = "Publisher Copyright: {\textcopyright} 2017, The Author(s).",

year = "2017",

month = sep,

doi = "10.1007/s00330-017-4770-7",

language = "English",

volume = "27",

pages = "3934–3941",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer-Verlag",

number = "9",

}

Sanders, MF, van Doormaal, PJ, Beeftink, MMA, Bots, ML, Fadl Elmula, FEM, Habets, J, Hammer, F, Hoffmann, P, Jacobs, L, Mark, PB, Persu, A, Renkin, J, Roditi, G, Spiering, W, Staessen, JA, Taylor, AH, Verloop, WL, Vink, EE, Vonken, E-J, Voskuil, M , Leiner, T, Blankestijn, PJ 2017, 'Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography', European Radiology, vol. 27, no. 9, pp. 3934–3941. https://doi.org/10.1007/s00330-017-4770-7

TY - JOUR

T1 - Renal artery and parenchymal changes after renal denervation

T2 - assessment by magnetic resonance angiography

AU - Sanders, Margreet F

AU - van Doormaal, Pieter Jan

AU - Beeftink, Martine M A

AU - Bots, Michiel L

AU - Fadl Elmula, Fadl Elmula M

AU - Habets, Jesse

AU - Hammer, Frank

AU - Hoffmann, Pavel

AU - Jacobs, Lotte

AU - Mark, Patrick B

AU - Persu, Alexandre

AU - Renkin, Jean

AU - Roditi, Giles

AU - Spiering, Wilko

AU - Staessen, Jan A

AU - Taylor, Alison H

AU - Verloop, Willemien L

AU - Vink, Eva E

AU - Vonken, Evert-Jan

AU - Voskuil, Michiel

AU - Leiner, Tim

AU - Blankestijn, Peter J

PY - 2017/9

Y1 - 2017/9

N2 - OBJECTIVES: Relatively little is known about the incidence of long-term renal damage after renal denervation (RDN), a potential new treatment for hypertension. In this study the incidence of renal artery and parenchymal changes, assessed with contrast-enhanced magnetic resonance angiography (MRA) after RDN, is investigated.METHODS: This study is an initiative of ENCOReD, a collaboration of hypertension expert centres. Patients in whom an MRA was performed before and after RDN were included. Scans were evaluated by two independent, blinded radiologists. Primary outcome was the change in renal artery morphology and parenchyma.RESULTS: MRAs from 96 patients were analysed. Before RDN, 41 renal anomalies were observed, of which 29 mostly mild renal artery stenoses. After a median time of 366 days post RDN, MRA showed a new stenosis (25-49% lumen reduction) in two patients and progression of pre-existing lumen reduction in a single patient. No other renal changes were observed and renal function remained stable.CONCLUSIONS: We observed new or progressed renal artery stenosis in three out of 96 patients, after a median time of 12 months post RDN (3.1%). Procedural angiographies showed that ablations were applied near the observed stenosis in only one of the three patients.KEY POINTS: • The incidence of vascular changes 12 months post RDN was 3.1%. • No renal vascular or parenchymal changes other than stenoses were observed. • Ablations were applied near the stenosis in only one of three patients.

AB - OBJECTIVES: Relatively little is known about the incidence of long-term renal damage after renal denervation (RDN), a potential new treatment for hypertension. In this study the incidence of renal artery and parenchymal changes, assessed with contrast-enhanced magnetic resonance angiography (MRA) after RDN, is investigated.METHODS: This study is an initiative of ENCOReD, a collaboration of hypertension expert centres. Patients in whom an MRA was performed before and after RDN were included. Scans were evaluated by two independent, blinded radiologists. Primary outcome was the change in renal artery morphology and parenchyma.RESULTS: MRAs from 96 patients were analysed. Before RDN, 41 renal anomalies were observed, of which 29 mostly mild renal artery stenoses. After a median time of 366 days post RDN, MRA showed a new stenosis (25-49% lumen reduction) in two patients and progression of pre-existing lumen reduction in a single patient. No other renal changes were observed and renal function remained stable.CONCLUSIONS: We observed new or progressed renal artery stenosis in three out of 96 patients, after a median time of 12 months post RDN (3.1%). Procedural angiographies showed that ablations were applied near the observed stenosis in only one of the three patients.KEY POINTS: • The incidence of vascular changes 12 months post RDN was 3.1%. • No renal vascular or parenchymal changes other than stenoses were observed. • Ablations were applied near the stenosis in only one of three patients.

U2 - 10.1007/s00330-017-4770-7

DO - 10.1007/s00330-017-4770-7

M3 - Article

C2 - 28271154

SN - 0938-7994

VL - 27

SP - 3934

EP - 3941

JO - European Radiology

JF - European Radiology

IS - 9

ER -

Renal artery and parenchymal changes after renal denervation: assessment by magnetic resonance angiography

Abstract

Access to Document

Fingerprint

Cite this