Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity

Femke F Wilms; Jolande Y Vis; Desiree A P M Pattinaja; Rosanna A Kuin; Monique C Stam; Janine M Reuvers; Ben Willem J Mol

doi:10.1016/j.ajog.2011.03.035

Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity

Femke F Wilms, Jolande Y Vis, Desiree A P M Pattinaja, Rosanna A Kuin, Monique C Stam, Janine M Reuvers, Ben Willem J Mol

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth.

STUDY DESIGN: We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity.

RESULTS: We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.1-5.4; OR, 5.6; 95% CI, 1.8-18; and OR, 4.8; 95% CI, 0.71-32, not statistically significant, respectively).

CONCLUSION: The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.

Original language	English
Pages (from-to)	49.e1-7
Journal	American Journal of Obstetrics and Gynecology
Volume	205
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2011.03.035
Publication status	Published - Jul 2011

Keywords

Adolescent
Adrenal Cortex Hormones
Adult
Cohort Studies
Drug Administration Schedule
Female
Humans
Infant, Newborn
Male
Pregnancy
Pregnancy Outcome
Premature Birth
Prenatal Care
Respiratory Distress Syndrome, Newborn
Retrospective Studies
Treatment Outcome
Young Adult

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Wilms, F. F., Vis, J. Y., Pattinaja, D. A. P. M., Kuin, R. A., Stam, M. C., Reuvers, J. M., & Mol, B. W. J. (2011). Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity. American Journal of Obstetrics and Gynecology, 205(1), 49.e1-7. https://doi.org/10.1016/j.ajog.2011.03.035

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abstract = "OBJECTIVE: The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth.STUDY DESIGN: We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity.RESULTS: We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.1-5.4; OR, 5.6; 95% CI, 1.8-18; and OR, 4.8; 95% CI, 0.71-32, not statistically significant, respectively).CONCLUSION: The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.",

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author = "Wilms, {Femke F} and Vis, {Jolande Y} and Pattinaja, {Desiree A P M} and Kuin, {Rosanna A} and Stam, {Monique C} and Reuvers, {Janine M} and Mol, {Ben Willem J}",

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doi = "10.1016/j.ajog.2011.03.035",

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Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity. / Wilms, Femke F; Vis, Jolande Y; Pattinaja, Desiree A P M et al.
In: American Journal of Obstetrics and Gynecology, Vol. 205, No. 1, 07.2011, p. 49.e1-7.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity

AU - Wilms, Femke F

AU - Vis, Jolande Y

AU - Pattinaja, Desiree A P M

AU - Kuin, Rosanna A

AU - Stam, Monique C

AU - Reuvers, Janine M

AU - Mol, Ben Willem J

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N2 - OBJECTIVE: The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth.STUDY DESIGN: We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity.RESULTS: We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.1-5.4; OR, 5.6; 95% CI, 1.8-18; and OR, 4.8; 95% CI, 0.71-32, not statistically significant, respectively).CONCLUSION: The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.

AB - OBJECTIVE: The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth.STUDY DESIGN: We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity.RESULTS: We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.1-5.4; OR, 5.6; 95% CI, 1.8-18; and OR, 4.8; 95% CI, 0.71-32, not statistically significant, respectively).CONCLUSION: The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.

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KW - Humans

KW - Infant, Newborn

KW - Male

KW - Pregnancy

KW - Pregnancy Outcome

KW - Premature Birth

KW - Prenatal Care

KW - Respiratory Distress Syndrome, Newborn

KW - Retrospective Studies

KW - Treatment Outcome

KW - Young Adult

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DO - 10.1016/j.ajog.2011.03.035

M3 - Article

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SN - 0002-9378

VL - 205

SP - 49.e1-7

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

IS - 1

ER -

Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity

Abstract

Keywords

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