Relation between clinical risk factors, early cortical changes, and neurodevelopmental outcome in preterm infants

Karina J. Kersbergen, François Leroy, Ivana Išgum, Floris Groenendaal, Linda S. de Vries, Nathalie H P Claessens, Ingrid C. van Haastert, Pim Moeskops, Clara Fischer, Jean François Mangin, Max A. Viergever, Jessica Dubois, Manon J N L Benders*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Cortical folding mainly takes place in the third trimester of pregnancy and may therefore be influenced by preterm birth. The aim of this study was to evaluate the development of specific cortical structures between early age (around 30weeks postmenstrual age) and term-equivalent age (TEA, around 40weeks postmenstrual age) in 71 extremely preterm infants, and to associate this to clinical characteristics and neurodevelopmental outcome at two years of age. First, analysis showed that the central sulcus (CS), lateral fissure (LF) and insula (INS) were present at early MRI in all infants, whereas the other sulci (post-central sulcus [PCS], superior temporal sulcus [STS], superior [SFS] and inferior [IFS] frontal sulcus) were only seen in part of the infants. Relative growth from early to TEA examination was largest in the SFS. A rightward asymmetry of the surface area was seen in development between both examinations except for the LF, which showed a leftward asymmetry at both time points. Second, lower birth weight z-score, multiple pregnancy and prolonged mechanical ventilation showed negative effects on cortical folding of the CS, LF, INS, STS and PCS, mainly on the first examination, suggesting that sulci developing the earliest were the most affected by clinical factors. Finally, in this cohort, a clear association between cortical folding and neurodevelopmental outcome at two years corrected age was found, particularly for receptive language.

Original languageEnglish
Pages (from-to)301–310
Number of pages10
Publication statusPublished - 15 Nov 2016


  • Asymmetry
  • Clinical data
  • Cortical folding
  • Neurodevelopmental outcome
  • Preterm infants


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