Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions

Sebastian Breuer; Katrin Pech; Armin Buss; Christoph Spitzer; Juris Ozols; Elly M Hol; Nicole Heussen; Johannes Noth; Franz-Werner Schwaiger; Andreas B Schmitt

doi:10.1186/1471-2202-5-15

Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions

Sebastian Breuer
, Katrin Pech
, Armin Buss
, Christoph Spitzer
, Juris Ozols
, Elly M Hol
, Nicole Heussen
, Johannes Noth
, Franz-Werner Schwaiger
, Andreas B Schmitt

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.

RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.

CONCLUSION: This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.

Original language	English
Pages (from-to)	15
Journal	BMC Neuroscience [E]
Volume	5
DOIs	https://doi.org/10.1186/1471-2202-5-15
Publication status	Published - 20 Apr 2004

Keywords

Animals
Axotomy
Central Nervous System
Disease Progression
Facial Nerve Injuries
Hypoglossal Nerve
Hypoglossal Nerve Injuries
Immunohistochemistry
In Situ Hybridization
Isoenzymes
Nerve Regeneration
Neurons
Peripheral Nervous System
Pons
RNA, Messenger
Rats
Rats, Sprague-Dawley
Red Nucleus
Spinal Cord Injuries
Stearoyl-CoA Desaturase
Trauma, Nervous System
Up-Regulation
Journal Article
Research Support, Non-U.S. Gov't

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10.1186/1471-2202-5-15

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title = "Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions",

abstract = "BACKGROUND: Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.CONCLUSION: This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.",

keywords = "Animals, Axotomy, Central Nervous System, Disease Progression, Facial Nerve Injuries, Hypoglossal Nerve, Hypoglossal Nerve Injuries, Immunohistochemistry, In Situ Hybridization, Isoenzymes, Nerve Regeneration, Neurons, Peripheral Nervous System, Pons, RNA, Messenger, Rats, Rats, Sprague-Dawley, Red Nucleus, Spinal Cord Injuries, Stearoyl-CoA Desaturase, Trauma, Nervous System, Up-Regulation, Journal Article, Research Support, Non-U.S. Gov't",

author = "Sebastian Breuer and Katrin Pech and Armin Buss and Christoph Spitzer and Juris Ozols and Hol, \{Elly M\} and Nicole Heussen and Johannes Noth and Franz-Werner Schwaiger and Schmitt, \{Andreas B\}",

year = "2004",

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doi = "10.1186/1471-2202-5-15",

language = "English",

volume = "5",

pages = "15",

journal = "BMC Neuroscience [E]",

issn = "1471-2202",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions

AU - Breuer, Sebastian

AU - Pech, Katrin

AU - Buss, Armin

AU - Spitzer, Christoph

AU - Ozols, Juris

AU - Hol, Elly M

AU - Heussen, Nicole

AU - Noth, Johannes

AU - Schwaiger, Franz-Werner

AU - Schmitt, Andreas B

PY - 2004/4/20

Y1 - 2004/4/20

N2 - BACKGROUND: Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.CONCLUSION: This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.

AB - BACKGROUND: Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.CONCLUSION: This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.

KW - Animals

KW - Axotomy

KW - Central Nervous System

KW - Disease Progression

KW - Facial Nerve Injuries

KW - Hypoglossal Nerve

KW - Hypoglossal Nerve Injuries

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Isoenzymes

KW - Nerve Regeneration

KW - Neurons

KW - Peripheral Nervous System

KW - Pons

KW - RNA, Messenger

KW - Rats

KW - Rats, Sprague-Dawley

KW - Red Nucleus

KW - Spinal Cord Injuries

KW - Stearoyl-CoA Desaturase

KW - Trauma, Nervous System

KW - Up-Regulation

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/1471-2202-5-15

DO - 10.1186/1471-2202-5-15

M3 - Article

C2 - 15099403

SN - 1471-2202

VL - 5

SP - 15

JO - BMC Neuroscience [E]

JF - BMC Neuroscience [E]

ER -

Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions

Abstract

Keywords

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