Abstract
Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis
| Translated title of the contribution | Regulation of Slow and Fast Muscle Myofibrillogenesis by Wnt/beta-Catenin and Myostatin Signaling |
|---|---|
| Original language | Undefined/Unknown |
| Pages (from-to) | e5880 |
| Number of pages | 1 |
| Journal | PLoS ONE [E] |
| Volume | 4 |
| Issue number | 6 |
| Publication status | Published - 2009 |