Regulation of Ras-mediated signalling: more than one way to skin a cat

Boudewijn M.T. Burgering; Johannes L. Bos

doi:10.1016/S0968-0004(00)88944-6

Regulation of Ras-mediated signalling: more than one way to skin a cat

Boudewijn M.T. Burgering^*
, Johannes L. Bos

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

279 Citations (Scopus)

Abstract

A powerful combination of genetics and biochemistry has provided details of how Ras-directed signalling interacts with and is regulated by other cellular signalling pathways. This might ultimately lead to the control of deregulated signalling by oncogenic Ras. Recently, progress has been made in understanding the regulation of Ras-mediated activation of the Raf-1-ERK2 kinase cascade through crosstalk with protein kinase C and cyclic-AMP-dependent protein kinase.

Original language	English
Pages (from-to)	18-22
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/S0968-0004(00)88944-6
Publication status	Published - 1 Jan 1995

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title = "Regulation of Ras-mediated signalling: more than one way to skin a cat",

abstract = "A powerful combination of genetics and biochemistry has provided details of how Ras-directed signalling interacts with and is regulated by other cellular signalling pathways. This might ultimately lead to the control of deregulated signalling by oncogenic Ras. Recently, progress has been made in understanding the regulation of Ras-mediated activation of the Raf-1-ERK2 kinase cascade through crosstalk with protein kinase C and cyclic-AMP-dependent protein kinase.",

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AB - A powerful combination of genetics and biochemistry has provided details of how Ras-directed signalling interacts with and is regulated by other cellular signalling pathways. This might ultimately lead to the control of deregulated signalling by oncogenic Ras. Recently, progress has been made in understanding the regulation of Ras-mediated activation of the Raf-1-ERK2 kinase cascade through crosstalk with protein kinase C and cyclic-AMP-dependent protein kinase.

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U2 - 10.1016/S0968-0004(00)88944-6

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Regulation of Ras-mediated signalling: more than one way to skin a cat

Abstract

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