TY - JOUR
T1 - Regulation of Ras-mediated signalling
T2 - more than one way to skin a cat
AU - Burgering, Boudewijn M.T.
AU - Bos, Johannes L.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - A powerful combination of genetics and biochemistry has provided details of how Ras-directed signalling interacts with and is regulated by other cellular signalling pathways. This might ultimately lead to the control of deregulated signalling by oncogenic Ras. Recently, progress has been made in understanding the regulation of Ras-mediated activation of the Raf-1-ERK2 kinase cascade through crosstalk with protein kinase C and cyclic-AMP-dependent protein kinase.
AB - A powerful combination of genetics and biochemistry has provided details of how Ras-directed signalling interacts with and is regulated by other cellular signalling pathways. This might ultimately lead to the control of deregulated signalling by oncogenic Ras. Recently, progress has been made in understanding the regulation of Ras-mediated activation of the Raf-1-ERK2 kinase cascade through crosstalk with protein kinase C and cyclic-AMP-dependent protein kinase.
UR - http://www.scopus.com/inward/record.url?scp=0028917954&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(00)88944-6
DO - 10.1016/S0968-0004(00)88944-6
M3 - Review article
C2 - 7878738
AN - SCOPUS:0028917954
SN - 0968-0004
VL - 20
SP - 18
EP - 22
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 1
ER -