TY - JOUR
T1 - Regulation and Dysregulation of Chromosome Structure in Cancer
AU - Hnisz, Denes
AU - Schuijers, Jurian
AU - Li, Charles H.
AU - Young, Richard A.
N1 - Publisher Copyright:
© 2018 by Annual Reviews.
PY - 2018
Y1 - 2018
N2 - Cancer arises from genetic alterations that produce dysregulated gene expression programs. Normal gene regulation occurs in the context of chromosome loop structures called insulated neighborhoods, and recent studies have shown that these structures are altered and can contribute to oncogene dysregulation in various cancer cells. We review the types of genetic and epigenetic alterations that influence neighborhood structures and contribute to gene dysregulation in cancer, present models for insulated neighborhoods associated with the most prominent human oncogenes, and discuss how such models may lead to further advances in cancer diagnosis and therapy.
AB - Cancer arises from genetic alterations that produce dysregulated gene expression programs. Normal gene regulation occurs in the context of chromosome loop structures called insulated neighborhoods, and recent studies have shown that these structures are altered and can contribute to oncogene dysregulation in various cancer cells. We review the types of genetic and epigenetic alterations that influence neighborhood structures and contribute to gene dysregulation in cancer, present models for insulated neighborhoods associated with the most prominent human oncogenes, and discuss how such models may lead to further advances in cancer diagnosis and therapy.
KW - chromosome structure
KW - insulated neighborhood
KW - oncogene regulation
UR - http://www.scopus.com/inward/record.url?scp=85045184031&partnerID=8YFLogxK
U2 - 10.1146/annurev-cancerbio-030617-050134
DO - 10.1146/annurev-cancerbio-030617-050134
M3 - Review article
AN - SCOPUS:85045184031
VL - 2
SP - 21
EP - 40
JO - Annual Review of Cancer Biology
JF - Annual Review of Cancer Biology
ER -