Reduction of pin tract infections during external fixation using cadexomer iodine

Mylène P. Jansen*, Nienke van Egmond, Esmee C. Kester, Simon C. Mastbergen, Floris P.J.G. Lafeber, Roel J.H. Custers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Downloads (Pure)


Purpose: Knee joint distraction (KJD) is a joint-preserving treatment for younger osteoarthritis patients. KJD has shown positive results in regular care, but the external fixation frame often caused pin tract skin infections. Therefore, the use of cadexomer iodine was included in the wound care protocol. The goal of this cross-sectional study was to evaluate whether use of this ointment reduced the number of patients with infections during KJD treatment. Methods: Patients treated with KJD in regular care were included if they gave consent for use of their data and completed treatment with the newest distraction device before 2020. All patients followed a wound care protocol, which since March 2019 included using cadexomer iodine ointment. The number of patients experiencing pin tract infections was compared between patients who did (March 2019–December 2019) and did not (November 2017–March 2019) use the ointment. Results: Sixty-seven patients were included; 34 patients used cadexomer iodine and 33 patients did not. Patient who did not use cadexomer iodine experienced twice as many infections (64% vs 32%;p = 0.010). There was a significant difference in the number of patients with serious infections, requiring more antibiotics than the standard 7-day oral antibiotics (30% without vs 6% with cadexomer iodine; p = 0.009). Conclusions: The use of cadexomer iodine ointment during KJD results in a significant reduction of the number of patients experiencing pin tract infections during treatment. Use of this ointment should be considered standard protocol during KJD treatment and could be of value in general external fixator usage as well.

Original languageEnglish
Article number88
Pages (from-to)1-6
JournalJournal of Experimental Orthopaedics
Issue number1
Publication statusPublished - 1 Dec 2020


  • Cadexomer iodine
  • External fixation
  • Infection
  • Joint distraction
  • Ointment
  • Pin track
  • Pin tract
  • Prevention
  • Regular care


Dive into the research topics of 'Reduction of pin tract infections during external fixation using cadexomer iodine'. Together they form a unique fingerprint.

Cite this