Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

J. S. Biswas; A. Patel; J. A. Otter; P. Wade; W. Newsholme; E. van Kleef; S. D. Goldenberg

doi:10.1016/j.jhin.2015.01.015

Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

J. S. Biswas, A. Patel, J. A. Otter, P. Wade, W. Newsholme, E. van Kleef, S. D. Goldenberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.

Original language	English
Pages (from-to)	267-270
Number of pages	4
Journal	Journal of Hospital Infection
Volume	90
Issue number	3
DOIs	https://doi.org/10.1016/j.jhin.2015.01.015
Publication status	Published - 1 Jul 2015
Externally published	Yes

Keywords

Clostridium difficile
Contamination
Environment
Fidaxomicin

Access to Document

10.1016/j.jhin.2015.01.015

Cite this

@article{36a52d883130485ca5971bb0a2a73b48,

title = "Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin",

abstract = "Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.",

keywords = "Clostridium difficile, Contamination, Environment, Fidaxomicin",

author = "Biswas, {J. S.} and A. Patel and Otter, {J. A.} and P. Wade and W. Newsholme and {van Kleef}, E. and Goldenberg, {S. D.}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.jhin.2015.01.015",

language = "English",

volume = "90",

pages = "267--270",

journal = "Journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

AU - Biswas, J. S.

AU - Patel, A.

AU - Otter, J. A.

AU - Wade, P.

AU - Newsholme, W.

AU - van Kleef, E.

AU - Goldenberg, S. D.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.

AB - Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.

KW - Clostridium difficile

KW - Contamination

KW - Environment

KW - Fidaxomicin

UR - http://www.scopus.com/inward/record.url?scp=84930572342&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2015.01.015

DO - 10.1016/j.jhin.2015.01.015

M3 - Article

C2 - 25728208

AN - SCOPUS:84930572342

SN - 0195-6701

VL - 90

SP - 267

EP - 270

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 3

ER -

Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this