TY - JOUR
T1 - Reduced survival after isoprenaline/dopamine in d,l-propranolol intoxicated rats
AU - Toet, A. E.
AU - Te Biesebeek, J. D.
AU - Vleeming, W.
AU - Wemer, J.
AU - Meulenbelt, J.
AU - De Wildt, D. J.
PY - 1996/2/1
Y1 - 1996/2/1
N2 - 1. Respiratory and cardiovascular failure are principle toxic effects of β-blocker overdose. Respiratory arrest is the primary cause of death in β-blocker intoxicated rats. 2. The effect of β-adrenoceptor agonists on respiratory and cardiovascular failure in β-blocker overdose was investigated in a model of acute d,l-propranolol (30 mg kg -1 h -1) intoxication in spontaneously breathing rats. 3. Neither the aselective, hydrophilic β-agonist isoprenaline (10, 25, 50 μg kg -1 min -1), nor the β 2-selective, lipophilic β-agonist flerobuterol (1, 3, 10 μg kg -1 min -1) and the β 2-selective, lipophilic β-agonist clenbuterol (10, 25, 50 μg kg -1 min -1) had any beneficial effect on cardiovascular and respiratory variables or survival time in d,l-propranolol intoxicated spontaneously breathing rats. 4. Isoprenaline (10 μg kg -1 min -1) had no favourable effect on haemodynamic and respiratory variables in artificially ventilated d,l-propranolol intoxicated rats either. 5. Addition of dopamine to isoprenaline resulted in a significant reduction of survival time, primarily caused by a decrease in mean arterial blood pressure, in artificially ventilated d,l-propranolol intoxicated rats. Addition of glucagon to isoprenaline did not affect survival time. 6. Artificial ventilation is the most important supportive measure in d,l-propranolol intoxication in the rat.
AB - 1. Respiratory and cardiovascular failure are principle toxic effects of β-blocker overdose. Respiratory arrest is the primary cause of death in β-blocker intoxicated rats. 2. The effect of β-adrenoceptor agonists on respiratory and cardiovascular failure in β-blocker overdose was investigated in a model of acute d,l-propranolol (30 mg kg -1 h -1) intoxication in spontaneously breathing rats. 3. Neither the aselective, hydrophilic β-agonist isoprenaline (10, 25, 50 μg kg -1 min -1), nor the β 2-selective, lipophilic β-agonist flerobuterol (1, 3, 10 μg kg -1 min -1) and the β 2-selective, lipophilic β-agonist clenbuterol (10, 25, 50 μg kg -1 min -1) had any beneficial effect on cardiovascular and respiratory variables or survival time in d,l-propranolol intoxicated spontaneously breathing rats. 4. Isoprenaline (10 μg kg -1 min -1) had no favourable effect on haemodynamic and respiratory variables in artificially ventilated d,l-propranolol intoxicated rats either. 5. Addition of dopamine to isoprenaline resulted in a significant reduction of survival time, primarily caused by a decrease in mean arterial blood pressure, in artificially ventilated d,l-propranolol intoxicated rats. Addition of glucagon to isoprenaline did not affect survival time. 6. Artificial ventilation is the most important supportive measure in d,l-propranolol intoxication in the rat.
KW - β-adrenoceptor agonists
KW - Dopamine
KW - Isoprenaline
KW - Propranolol intoxication
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=0030045832&partnerID=8YFLogxK
M3 - Article
C2 - 8645502
AN - SCOPUS:0030045832
SN - 0144-5952
VL - 15
SP - 120
EP - 128
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
IS - 2
ER -