TY - JOUR
T1 - Reduced renal length and volume 20 years after very preterm birth
AU - Keijzer-Veen, Mandy G.
AU - Devos, Annick S.
AU - Meradji, Morteza
AU - Dekker, Friedo W.
AU - Nauta, Jeroen
AU - Van Der Heijden, Bert J.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Intrauterine growth retardation is presumed to be associated with decreased renal size and impaired renal function as a result of stunted kidney development and nephron deficit. To study whether very preterm birth also affects renal size at young adulthood, we sonographically measured bipolar kidney length and volume in 51 very premature individuals (<32 weeks of gestation), either small (SGA) or appropriate (AGA) for gestational age (22 SGA and 29 AGA), and 30 full-term controls 20 years after birth. Relative kidney length and volume were calculated. Both absolute and relative left kidney length and volume were significantly lower in SGA and AGA individuals, otably in women. Renal size did not differ between SGA and AGA individuals. In 70% of controls, the left kidney was larger than the right one compared with 40.9% in SGA [relative risk (RR) 1.7; 95% confidence interval (CI) 1.0 -3.0] and 48.3% in AGA (RR 1.5; 95% CI 0.9-2.3) individuals. Renal structural anomalies were present in eight prematurely born participants only. Our data suggest that kidney growth is stunted after preterm birth, especially on the left side, and in the female gender.
AB - Intrauterine growth retardation is presumed to be associated with decreased renal size and impaired renal function as a result of stunted kidney development and nephron deficit. To study whether very preterm birth also affects renal size at young adulthood, we sonographically measured bipolar kidney length and volume in 51 very premature individuals (<32 weeks of gestation), either small (SGA) or appropriate (AGA) for gestational age (22 SGA and 29 AGA), and 30 full-term controls 20 years after birth. Relative kidney length and volume were calculated. Both absolute and relative left kidney length and volume were significantly lower in SGA and AGA individuals, otably in women. Renal size did not differ between SGA and AGA individuals. In 70% of controls, the left kidney was larger than the right one compared with 40.9% in SGA [relative risk (RR) 1.7; 95% confidence interval (CI) 1.0 -3.0] and 48.3% in AGA (RR 1.5; 95% CI 0.9-2.3) individuals. Renal structural anomalies were present in eight prematurely born participants only. Our data suggest that kidney growth is stunted after preterm birth, especially on the left side, and in the female gender.
KW - Developmental origins of health and disease
KW - Intrauterine growth retardation
KW - Kidney development
KW - Preterm birth
KW - Renal growth
KW - Renal ultrasound
UR - https://www.scopus.com/pages/publications/77950360798
U2 - 10.1007/s00467-009-1371-y
DO - 10.1007/s00467-009-1371-y
M3 - Article
C2 - 20013294
AN - SCOPUS:77950360798
SN - 0931-041X
VL - 25
SP - 499
EP - 507
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 3
ER -