Reduced fat oxidation rates during submaximal exercise in boys with cystic fibrosis

Background: Exercise is a viable form of therapy for children with cystic fibrosis (CF). Understanding the energy sources used during exercise would aid CF patients in obtaining proper nutrition in order to sustain an active lifestyle.

Methods: Six boys with CF (mean age SD: 14.8 +/- 2.3 yrs, FEV1: 99 +/- 18% predicted) and six matched controls (14.0 +/- 2.2 yrs) completed a session of two 30 min bouts of cycling at an intensity set at 50% peak mechanical power. Rates of total fat and carbohydrate (CHO) oxidation were calculated from expired gases. Plasma insulin, glucose and free fatty acid (FFA) were determined before, during and at the end of the exercise.

Results: Rates of fat oxidation (expressed in mean mg x kg body weight(-1) x min(-1) +/- SD) were significantly lower in children with CF (5.7 +/- 1.6) compared to controls (8.6 +/- 1.8, p <0.05). Children with CF also had lower values than controls in amount of fat oxidized (CF: 17.3 +/- 5.0 g, controls. 26.1 +/- 5.9 g, p <0.05) and percent of total energy expenditure from fat (CF: 32 +/- 6%, controls: 43 +/- 7%, p

Conclusion: Fat metabolism during exercise is impaired in boys with CF and may be attributed to an inability to mobilize FFA. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.