Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Gitte Berkers, Peter van Mourik, Annelotte M Vonk, Evelien Kruisselbrink, Johanna F Dekkers, Karin M de Winter-de Groot, Hubertus G M Arets, Rozemarijn E P Marck-van der Wilt, Jasper S Dijkema, Maaike M Vanderschuren, Roderick H J Houwen, Harry G M Heijerman, Eduard A van de Graaf, Sjoerd G Elias, Christof J Majoor, Gerard H Koppelman, Jolt Roukema, Marleen Bakker, Hettie M Janssens, Renske van der MeerRobert G J Vries, Hans C Clevers, Hugo R de Jonge, Jeffrey M Beekman, Cornelis K van der Ent

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

Original languageEnglish
Pages (from-to)1701-1708.e3
JournalCell Reports
Volume26
Issue number7
DOIs
Publication statusPublished - 12 Feb 2019

Keywords

  • CFTR
  • cystic fibrosis
  • drug response
  • organoids
  • personalized treatment
  • predicting
  • stem cell cultures

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