Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Gitte Berkers; Peter van Mourik; Annelotte M Vonk; Evelien Kruisselbrink; Johanna F Dekkers; Karin M de Winter-de Groot; Hubertus G M Arets; Rozemarijn E P Marck-van der Wilt; Jasper S Dijkema; Maaike M Vanderschuren; Roderick H J Houwen; Harry G M Heijerman; Eduard A van de Graaf; Sjoerd G Elias; Christof J Majoor; Gerard H Koppelman; Jolt Roukema; Marleen Bakker; Hettie M Janssens; Renske van der Meer; Robert G J Vries; Hans C Clevers; Hugo R de Jonge; Jeffrey M Beekman; Cornelis K van der Ent

doi:10.1016/j.celrep.2019.01.068

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Gitte Berkers, Peter van Mourik, Annelotte M Vonk, Evelien Kruisselbrink, Johanna F Dekkers, Karin M de Winter-de Groot, Hubertus G M Arets, Rozemarijn E P Marck-van der Wilt, Jasper S Dijkema, Maaike M Vanderschuren, Roderick H J Houwen, Harry G M Heijerman, Eduard A van de Graaf, Sjoerd G Elias, Christof J Majoor, Gerard H Koppelman, Jolt Roukema, Marleen Bakker, Hettie M Janssens, Renske van der MeerRobert G J Vries, Hans C Clevers, Hugo R de Jonge, Jeffrey M Beekman, Cornelis K van der Ent

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Abstract

Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

Original language	English
Pages (from-to)	1701-1708.e3
Journal	Cell Reports
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2019.01.068
Publication status	Published - 12 Feb 2019

Keywords

CFTR
cystic fibrosis
drug response
organoids
personalized treatment
predicting
stem cell cultures

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10.1016/j.celrep.2019.01.068

berkersFinal published version, 2.31 MBLicence: CC BY-NC-ND

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Berkers, G., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Dekkers, J. F., de Winter-de Groot, K. M., Arets, H. G. M., Marck-van der Wilt, R. E. P., Dijkema, J. S., Vanderschuren, M. M., Houwen, R. H. J., Heijerman, H. G. M., van de Graaf, E. A., Elias, S. G., Majoor, C. J., Koppelman, G. H., Roukema, J., Bakker, M., Janssens, H. M., ... van der Ent, C. K. (2019). Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis. Cell Reports, 26(7), 1701-1708.e3. https://doi.org/10.1016/j.celrep.2019.01.068

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title = "Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis",

abstract = "Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.",

keywords = "CFTR, cystic fibrosis, drug response, organoids, personalized treatment, predicting, stem cell cultures",

author = "Gitte Berkers and {van Mourik}, Peter and Vonk, {Annelotte M} and Evelien Kruisselbrink and Dekkers, {Johanna F} and {de Winter-de Groot}, {Karin M} and Arets, {Hubertus G M} and {Marck-van der Wilt}, {Rozemarijn E P} and Dijkema, {Jasper S} and Vanderschuren, {Maaike M} and Houwen, {Roderick H J} and Heijerman, {Harry G M} and {van de Graaf}, {Eduard A} and Elias, {Sjoerd G} and Majoor, {Christof J} and Koppelman, {Gerard H} and Jolt Roukema and Marleen Bakker and Janssens, {Hettie M} and {van der Meer}, Renske and Vries, {Robert G J} and Clevers, {Hans C} and {de Jonge}, {Hugo R} and Beekman, {Jeffrey M} and {van der Ent}, {Cornelis K}",

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year = "2019",

month = feb,

day = "12",

doi = "10.1016/j.celrep.2019.01.068",

language = "English",

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Berkers, G, van Mourik, P, Vonk, AM, Kruisselbrink, E, Dekkers, JF, de Winter-de Groot, KM, Arets, HGM, Marck-van der Wilt, REP, Dijkema, JS, Vanderschuren, MM, Houwen, RHJ , Heijerman, HGM, van de Graaf, EA, Elias, SG, Majoor, CJ, Koppelman, GH, Roukema, J, Bakker, M, Janssens, HM, van der Meer, R, Vries, RGJ, Clevers, HC, de Jonge, HR, Beekman, JM & van der Ent, CK 2019, 'Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis', Cell Reports, vol. 26, no. 7, pp. 1701-1708.e3. https://doi.org/10.1016/j.celrep.2019.01.068

TY - JOUR

T1 - Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

AU - Berkers, Gitte

AU - van Mourik, Peter

AU - Vonk, Annelotte M

AU - Kruisselbrink, Evelien

AU - Dekkers, Johanna F

AU - de Winter-de Groot, Karin M

AU - Arets, Hubertus G M

AU - Marck-van der Wilt, Rozemarijn E P

AU - Dijkema, Jasper S

AU - Vanderschuren, Maaike M

AU - Houwen, Roderick H J

AU - Heijerman, Harry G M

AU - van de Graaf, Eduard A

AU - Elias, Sjoerd G

AU - Majoor, Christof J

AU - Koppelman, Gerard H

AU - Roukema, Jolt

AU - Bakker, Marleen

AU - Janssens, Hettie M

AU - van der Meer, Renske

AU - Vries, Robert G J

AU - Clevers, Hans C

AU - de Jonge, Hugo R

AU - Beekman, Jeffrey M

AU - van der Ent, Cornelis K

PY - 2019/2/12

Y1 - 2019/2/12

N2 - Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

AB - Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.

KW - CFTR

KW - cystic fibrosis

KW - drug response

KW - organoids

KW - personalized treatment

KW - predicting

KW - stem cell cultures

U2 - 10.1016/j.celrep.2019.01.068

DO - 10.1016/j.celrep.2019.01.068

M3 - Article

C2 - 30759382

SN - 2211-1247

VL - 26

SP - 1701-1708.e3

JO - Cell Reports

JF - Cell Reports

IS - 7

ER -

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

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Keywords

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