Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age

James Cohen Stuart; Sanquin Hamann; Jan Borleffs; Marijke Roos; Frank Miedema; Charles Boucher; Rob de Boer

doi:10.1097/00002030-200211220-00005

Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age

James Cohen Stuart, Sanquin Hamann, Jan Borleffs, Marijke Roos, Frank Miedema, Charles Boucher, Rob de Boer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To determine the influence of age on the regeneration rate of naive and memory T cells in the blood of 45 adults on highly active antiretroviral therapy (HAART).

METHODS: The age of the patients ranged from 25 to 57 years. Naive cells were defined as CD45RA+CD27+. Cells negative for CD45RA and/or CD27 were considered memory type cells.

RESULTS: The recovery rates of naive CD4 and CD8 T cells were similar, were negatively correlated with age and were decreasing 5% and 3.6% per year, respectively. In a multivariate regression analysis, only age was significantly correlated with the naive T cell recovery rates. The recovery rate of memory T cells showed no relation to age. The average regeneration rate of naive CD4 T cells during HAART, i.e., 0.34 x 10(6) cells/l per day, is not lower than regeneration rates in HIV-negative adults following cytotoxic chemotherapy or CD4 monoclonal antibody therapy.

CONCLUSION: These observations suggest that the thymus contributes considerably to the regeneration of naive T cells in adults on HAART, and that the impact of HIV infection on naive T cell production is small, or rapidly reversible.

Original language	English
Pages (from-to)	2263-6
Number of pages	4
Journal	AIDS (London, England)
Volume	16
Issue number	17
DOIs	https://doi.org/10.1097/00002030-200211220-00005
Publication status	Published - 22 Nov 2002
Externally published	Yes

Keywords

Adult
Aging/immunology
Anti-HIV Agents/therapeutic use
Antiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes/drug effects
CD8-Positive T-Lymphocytes/drug effects
Follow-Up Studies
HIV Infections/drug therapy
Humans
Leukocyte Common Antigens/analysis
Lymphocyte Count
Middle Aged
Multivariate Analysis
T-Lymphocyte Subsets/drug effects
Tumor Necrosis Factor Receptor Superfamily, Member 7/analysis

Access to Document

10.1097/00002030-200211220-00005

Cite this

@article{cf1c24433d5d48d3a2afbd5bfc5f731d,

title = "Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age",

abstract = "OBJECTIVE: To determine the influence of age on the regeneration rate of naive and memory T cells in the blood of 45 adults on highly active antiretroviral therapy (HAART).METHODS: The age of the patients ranged from 25 to 57 years. Naive cells were defined as CD45RA+CD27+. Cells negative for CD45RA and/or CD27 were considered memory type cells.RESULTS: The recovery rates of naive CD4 and CD8 T cells were similar, were negatively correlated with age and were decreasing 5% and 3.6% per year, respectively. In a multivariate regression analysis, only age was significantly correlated with the naive T cell recovery rates. The recovery rate of memory T cells showed no relation to age. The average regeneration rate of naive CD4 T cells during HAART, i.e., 0.34 x 10(6) cells/l per day, is not lower than regeneration rates in HIV-negative adults following cytotoxic chemotherapy or CD4 monoclonal antibody therapy.CONCLUSION: These observations suggest that the thymus contributes considerably to the regeneration of naive T cells in adults on HAART, and that the impact of HIV infection on naive T cell production is small, or rapidly reversible.",

keywords = "Adult, Aging/immunology, Anti-HIV Agents/therapeutic use, Antiretroviral Therapy, Highly Active, CD4-Positive T-Lymphocytes/drug effects, CD8-Positive T-Lymphocytes/drug effects, Follow-Up Studies, HIV Infections/drug therapy, Humans, Leukocyte Common Antigens/analysis, Lymphocyte Count, Middle Aged, Multivariate Analysis, T-Lymphocyte Subsets/drug effects, Tumor Necrosis Factor Receptor Superfamily, Member 7/analysis",

author = "{Cohen Stuart}, James and Sanquin Hamann and Jan Borleffs and Marijke Roos and Frank Miedema and Charles Boucher and {de Boer}, Rob",

year = "2002",

month = nov,

day = "22",

doi = "10.1097/00002030-200211220-00005",

language = "English",

volume = "16",

pages = "2263--6",

journal = "AIDS (London, England)",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins",

number = "17",

}

TY - JOUR

T1 - Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age

AU - Cohen Stuart, James

AU - Hamann, Sanquin

AU - Borleffs, Jan

AU - Roos, Marijke

AU - Miedema, Frank

AU - Boucher, Charles

AU - de Boer, Rob

PY - 2002/11/22

Y1 - 2002/11/22

N2 - OBJECTIVE: To determine the influence of age on the regeneration rate of naive and memory T cells in the blood of 45 adults on highly active antiretroviral therapy (HAART).METHODS: The age of the patients ranged from 25 to 57 years. Naive cells were defined as CD45RA+CD27+. Cells negative for CD45RA and/or CD27 were considered memory type cells.RESULTS: The recovery rates of naive CD4 and CD8 T cells were similar, were negatively correlated with age and were decreasing 5% and 3.6% per year, respectively. In a multivariate regression analysis, only age was significantly correlated with the naive T cell recovery rates. The recovery rate of memory T cells showed no relation to age. The average regeneration rate of naive CD4 T cells during HAART, i.e., 0.34 x 10(6) cells/l per day, is not lower than regeneration rates in HIV-negative adults following cytotoxic chemotherapy or CD4 monoclonal antibody therapy.CONCLUSION: These observations suggest that the thymus contributes considerably to the regeneration of naive T cells in adults on HAART, and that the impact of HIV infection on naive T cell production is small, or rapidly reversible.

AB - OBJECTIVE: To determine the influence of age on the regeneration rate of naive and memory T cells in the blood of 45 adults on highly active antiretroviral therapy (HAART).METHODS: The age of the patients ranged from 25 to 57 years. Naive cells were defined as CD45RA+CD27+. Cells negative for CD45RA and/or CD27 were considered memory type cells.RESULTS: The recovery rates of naive CD4 and CD8 T cells were similar, were negatively correlated with age and were decreasing 5% and 3.6% per year, respectively. In a multivariate regression analysis, only age was significantly correlated with the naive T cell recovery rates. The recovery rate of memory T cells showed no relation to age. The average regeneration rate of naive CD4 T cells during HAART, i.e., 0.34 x 10(6) cells/l per day, is not lower than regeneration rates in HIV-negative adults following cytotoxic chemotherapy or CD4 monoclonal antibody therapy.CONCLUSION: These observations suggest that the thymus contributes considerably to the regeneration of naive T cells in adults on HAART, and that the impact of HIV infection on naive T cell production is small, or rapidly reversible.

KW - Adult

KW - Aging/immunology

KW - Anti-HIV Agents/therapeutic use

KW - Antiretroviral Therapy, Highly Active

KW - CD4-Positive T-Lymphocytes/drug effects

KW - CD8-Positive T-Lymphocytes/drug effects

KW - Follow-Up Studies

KW - HIV Infections/drug therapy

KW - Humans

KW - Leukocyte Common Antigens/analysis

KW - Lymphocyte Count

KW - Middle Aged

KW - Multivariate Analysis

KW - T-Lymphocyte Subsets/drug effects

KW - Tumor Necrosis Factor Receptor Superfamily, Member 7/analysis

U2 - 10.1097/00002030-200211220-00005

DO - 10.1097/00002030-200211220-00005

M3 - Article

C2 - 12441797

SN - 0269-9370

VL - 16

SP - 2263

EP - 2266

JO - AIDS (London, England)

JF - AIDS (London, England)

IS - 17

ER -

Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age

Abstract

Keywords

Access to Document

Fingerprint

Cite this