Recent updates in the indolent lymphomas: Update on marginal zone lymphoma and Waldenström's macroglobulinemia

Karima Amaador, Catherine Thieblemont, Judith Trotman, Monique C Minnema

Research output: Contribution to journalReview articlepeer-review

Abstract

Marginal Zone Lymphoma (MZL) and Waldenström's Macroglobulinemia (WM) are indolent lymphomas that both arise from post germinal center lymphocytes. Both can secrete a monoclonal protein but high levels are mostly only seen in WM. The MYD88 L256P somatic mutation that is present in an estimated 95% of patients with WM has helped greatly in differentiating the two lymphomas. Several large clinical studies with new drugs have been performed that have provided new treatment options for both MZL and WM patients. In this short review we will discuss the recent literature published and provide some recommendations.

Original languageEnglish
Article numbere3210
JournalHematological Oncology
Volume42
Issue number6
Early online date17 Jul 2023
DOIs
Publication statusPublished - Nov 2024

Keywords

  • marginal zone lymphoma
  • treatment
  • Waldenstrom macroglobulinemia

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