Recent advances in viral evasion of the MHC Class I processing pathway

Anouk Bc Schuren; AI Correia de Almeida Costa; Emmanuel Jhj Wiertz

doi:10.1016/j.coi.2016.02.007

Recent advances in viral evasion of the MHC Class I processing pathway

Anouk Bc Schuren, AI Correia de Almeida Costa, Emmanuel Jhj Wiertz

Research output: Contribution to journal › Review article › peer-review

Abstract

T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses have evolved several mechanisms to avoid recognition, many of which target the MHC-I antigen-processing pathway. While many immune evasion strategies have been described in the context of herpesvirus infections, it is becoming clear that this 'disguise' ability is more widespread. Here, we address recent findings in viral evasion of the MHC-I antigen presentation pathway and the impact on CD8(+) T cell responses.

Original language	English
Pages (from-to)	43-50
Number of pages	8
Journal	Current Opinion in Immunology
Volume	40
DOIs	https://doi.org/10.1016/j.coi.2016.02.007
Publication status	Published - Jun 2016

Keywords

Animals
Antigen Presentation
Antigens, Viral
CD8-Positive T-Lymphocytes
Cytotoxicity, Immunologic
Gene Expression Regulation
Histocompatibility Antigens Class I
Humans
Immune Evasion
Killer Cells, Natural
Virus Diseases
Viruses
Journal Article
Review

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10.1016/j.coi.2016.02.007

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title = "Recent advances in viral evasion of the MHC Class I processing pathway",

abstract = "T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses have evolved several mechanisms to avoid recognition, many of which target the MHC-I antigen-processing pathway. While many immune evasion strategies have been described in the context of herpesvirus infections, it is becoming clear that this 'disguise' ability is more widespread. Here, we address recent findings in viral evasion of the MHC-I antigen presentation pathway and the impact on CD8(+) T cell responses.",

keywords = "Animals, Antigen Presentation, Antigens, Viral, CD8-Positive T-Lymphocytes, Cytotoxicity, Immunologic, Gene Expression Regulation, Histocompatibility Antigens Class I, Humans, Immune Evasion, Killer Cells, Natural, Virus Diseases, Viruses, Journal Article, Review",

author = "Schuren, \{Anouk Bc\} and \{Correia de Almeida Costa\}, AI and Wiertz, \{Emmanuel Jhj\}",

note = "Copyright {\textcopyright} 2016. Published by Elsevier Ltd.",

year = "2016",

month = jun,

doi = "10.1016/j.coi.2016.02.007",

language = "English",

volume = "40",

pages = "43--50",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Recent advances in viral evasion of the MHC Class I processing pathway

AU - Schuren, Anouk Bc

AU - Correia de Almeida Costa, AI

AU - Wiertz, Emmanuel Jhj

PY - 2016/6

Y1 - 2016/6

N2 - T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses have evolved several mechanisms to avoid recognition, many of which target the MHC-I antigen-processing pathway. While many immune evasion strategies have been described in the context of herpesvirus infections, it is becoming clear that this 'disguise' ability is more widespread. Here, we address recent findings in viral evasion of the MHC-I antigen presentation pathway and the impact on CD8(+) T cell responses.

AB - T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses have evolved several mechanisms to avoid recognition, many of which target the MHC-I antigen-processing pathway. While many immune evasion strategies have been described in the context of herpesvirus infections, it is becoming clear that this 'disguise' ability is more widespread. Here, we address recent findings in viral evasion of the MHC-I antigen presentation pathway and the impact on CD8(+) T cell responses.

KW - Animals

KW - Antigen Presentation

KW - Antigens, Viral

KW - CD8-Positive T-Lymphocytes

KW - Cytotoxicity, Immunologic

KW - Gene Expression Regulation

KW - Histocompatibility Antigens Class I

KW - Humans

KW - Immune Evasion

KW - Killer Cells, Natural

KW - Virus Diseases

KW - Viruses

KW - Journal Article

KW - Review

U2 - 10.1016/j.coi.2016.02.007

DO - 10.1016/j.coi.2016.02.007

M3 - Review article

C2 - 27065088

SN - 0952-7915

VL - 40

SP - 43

EP - 50

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

Recent advances in viral evasion of the MHC Class I processing pathway

Abstract

Keywords

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