Reactogenicity of acellular pertussis vaccine in 4-year-olds in The Netherlands

MG Keijzer-Veen; LHVD Wekken; RE Juttmann; R de Groot; HC Rumke

doi:10.1016/j.vaccine.2004.03.010

Reactogenicity of acellular pertussis vaccine in 4-year-olds in The Netherlands

MG Keijzer-Veen
, LHVD Wekken
, RE Juttmann
, R de Groot
, HC Rumke^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim: To observe reactogenicity of a three-component acellular pertussis (aP) vaccine simultaneously given with dT-IPV vaccine at the age of 4 years. Results: Of 813 subjects 36% had no adverse events. At the first day the score for pain was 47-55% (aP versus dT-IPV), for redness 3-4% and for swelling 5-6%. Irritability and loss of appetite had a score of 20%. In 3% of the children fever was present. Most symptoms disappeared within 3 days. Conclusion: Boostervaccination with an aP vaccine simultaneously given with dT-IPV vaccine at the age of 4 years is well tolerated. (C) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3256-3257
Number of pages	2
Journal	Vaccine
Volume	22
Issue number	25-26
DOIs	https://doi.org/10.1016/j.vaccine.2004.03.010
Publication status	Published - 3 Sept 2004
Externally published	Yes

Keywords

acellular pertussis vaccine
reactogenicity
booster vaccination
IMMUNOGENICITY
BOOSTER

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10.1016/j.vaccine.2004.03.010

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title = "Reactogenicity of acellular pertussis vaccine in 4-year-olds in The Netherlands",

abstract = "Aim: To observe reactogenicity of a three-component acellular pertussis (aP) vaccine simultaneously given with dT-IPV vaccine at the age of 4 years. Results: Of 813 subjects 36\% had no adverse events. At the first day the score for pain was 47-55\% (aP versus dT-IPV), for redness 3-4\% and for swelling 5-6\%. Irritability and loss of appetite had a score of 20\%. In 3\% of the children fever was present. Most symptoms disappeared within 3 days. Conclusion: Boostervaccination with an aP vaccine simultaneously given with dT-IPV vaccine at the age of 4 years is well tolerated. (C) 2004 Elsevier Ltd. All rights reserved.",

keywords = "acellular pertussis vaccine, reactogenicity, booster vaccination, IMMUNOGENICITY, BOOSTER",

author = "MG Keijzer-Veen and LHVD Wekken and RE Juttmann and \{de Groot\}, R and HC Rumke",

year = "2004",

month = sep,

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doi = "10.1016/j.vaccine.2004.03.010",

language = "English",

volume = "22",

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journal = "Vaccine",

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number = "25-26",

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TY - JOUR

T1 - Reactogenicity of acellular pertussis vaccine in 4-year-olds in The Netherlands

AU - Keijzer-Veen, MG

AU - Wekken, LHVD

AU - Juttmann, RE

AU - de Groot, R

AU - Rumke, HC

PY - 2004/9/3

Y1 - 2004/9/3

N2 - Aim: To observe reactogenicity of a three-component acellular pertussis (aP) vaccine simultaneously given with dT-IPV vaccine at the age of 4 years. Results: Of 813 subjects 36% had no adverse events. At the first day the score for pain was 47-55% (aP versus dT-IPV), for redness 3-4% and for swelling 5-6%. Irritability and loss of appetite had a score of 20%. In 3% of the children fever was present. Most symptoms disappeared within 3 days. Conclusion: Boostervaccination with an aP vaccine simultaneously given with dT-IPV vaccine at the age of 4 years is well tolerated. (C) 2004 Elsevier Ltd. All rights reserved.

AB - Aim: To observe reactogenicity of a three-component acellular pertussis (aP) vaccine simultaneously given with dT-IPV vaccine at the age of 4 years. Results: Of 813 subjects 36% had no adverse events. At the first day the score for pain was 47-55% (aP versus dT-IPV), for redness 3-4% and for swelling 5-6%. Irritability and loss of appetite had a score of 20%. In 3% of the children fever was present. Most symptoms disappeared within 3 days. Conclusion: Boostervaccination with an aP vaccine simultaneously given with dT-IPV vaccine at the age of 4 years is well tolerated. (C) 2004 Elsevier Ltd. All rights reserved.

KW - acellular pertussis vaccine

KW - reactogenicity

KW - booster vaccination

KW - IMMUNOGENICITY

KW - BOOSTER

U2 - 10.1016/j.vaccine.2004.03.010

DO - 10.1016/j.vaccine.2004.03.010

M3 - Article

C2 - 15308347

SN - 0264-410X

VL - 22

SP - 3256

EP - 3257

JO - Vaccine

JF - Vaccine

IS - 25-26

ER -

Reactogenicity of acellular pertussis vaccine in 4-year-olds in The Netherlands

Abstract

Keywords

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