Reactive astrogliosis in the era of single-cell transcriptomics

Zuzana Matusova, Elly M. Hol, Milos Pekny, Mikael Kubista, Lukas Valihrach*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

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Abstract

Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and function. Reactive astrocytes are important in the onset and progression of many neuropathologies, such as neurotrauma, stroke, and neurodegenerative diseases. Single-cell transcriptomics has revealed remarkable heterogeneity of reactive astrocytes, indicating their multifaceted functions in a whole spectrum of neuropathologies, with important temporal and spatial resolution, both in the brain and in the spinal cord. Interestingly, transcriptomic signatures of reactive astrocytes partially overlap between neurological diseases, suggesting shared and unique gene expression patterns in response to individual neuropathologies. In the era of single-cell transcriptomics, the number of new datasets steeply increases, and they often benefit from comparisons and integration with previously published work. Here, we provide an overview of reactive astrocyte populations defined by single-cell or single-nucleus transcriptomics across multiple neuropathologies, attempting to facilitate the search for relevant reference points and to improve the interpretability of new datasets containing cells with signatures of reactive astrocytes.

Original languageEnglish
Article number1173200
JournalFrontiers in Cellular Neuroscience
Volume17
DOIs
Publication statusPublished - 2023

Keywords

  • astrocytes
  • cell populations
  • CNS diseases
  • neurodegeneration
  • neuroinflammation
  • reactive astrogliosis
  • single-cell RNA-seq

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